Improved insulin action following short-term exercise training: role of energy and carbohydrate balance

被引:46
作者
Black, SE [1 ]
Mitchell, E [1 ]
Freedson, PS [1 ]
Chipkin, SR [1 ]
Braun, B [1 ]
机构
[1] Univ Massachusetts, Dept Exercise Sci, Amherst, MA 01003 USA
关键词
insulin resistance; stable isotope; glucose uptake; adipokine; leptin;
D O I
10.1152/japplphysiol.00291.2005
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Short- term exercise training improves insulin action, but the impact of replacing the energy expended during exercise to prevent energy deficit is unclear. The purpose of this study was to establish the role of an energy deficit in mediating improved insulin action after short- term exercise training. Two groups of previously sedentary, overweight/ obese subjects performed 6 consecutive days of moderate- intensity walking to expend similar to 500 kcal/ day. In one group, energy and carbohydrate expended during exercise was replaced [ balance group ( BAL), n = 8] and in the other group, energy was not replaced [ deficit group ( DEF), n = 8]. Insulin action ( blood glucose uptake during glucose infusion) and selected lipids and adipokines were measured pre- and posttraining. Training increased estimated daily energy expenditure by similar to 500 kcal/ day ( DEF = 469 +/- 45, BAL = 521 +/- 48), generating an energy deficit in DEF ( - 481 +/- 24 kcal/ day) but not BAL ( + 8 +/- 20 kcal/ day). Insulin action increased 40% in DEF ( P = 0.032) but not BAL ( - 8.4%, P = 0.107). Hepatic glucose production was suppressed during glucose infusion in DEF ( 30.2 +/- 9.5%, P = 0.037) but not BAL ( - 10.0 +/- 7.4%, P = 0.417). Fasting leptin concentrations declined in DEF but not BAL. Six days of exercise training without energy replacement significantly increased insulin action. Restoring energy balance by refeeding the energy and carbohydrate expended during exercise resulted in no change in insulin action. These findings suggest that changes in short- term energy and/ or carbohydrate balance play a key role in mediating the beneficial effects of exercise on whole body and hepatic insulin action.
引用
收藏
页码:2285 / 2293
页数:9
相关论文
共 53 条
[1]   Comparison of short-term diet and exercise on insulin action in individuals with abnormal glucose tolerance [J].
Arciero, PJ ;
Vukovich, MD ;
Holloszy, JO ;
Racette, SB ;
Kohrt, WM .
JOURNAL OF APPLIED PHYSIOLOGY, 1999, 86 (06) :1930-1935
[2]   Insulin resistance in obesity: body-weight or energy balance? [J].
Assali, AR ;
Ganor, A ;
Beigel, Y ;
Shafer, Z ;
Hershcovici, T ;
Fainaru, M .
JOURNAL OF ENDOCRINOLOGY, 2001, 171 (02) :293-298
[3]   EFFECT OF MUSCLE GLYCOGEN DEPLETION ON INVIVO INSULIN ACTION IN MAN [J].
BOGARDUS, C ;
THUILLEZ, P ;
RAVUSSIN, E ;
VASQUEZ, B ;
NARIMIGA, M ;
AZHAR, S .
JOURNAL OF CLINICAL INVESTIGATION, 1983, 72 (05) :1605-1610
[4]   EFFECTS OF EXERCISE INTENSITY ON INSULIN SENSITIVITY IN WOMEN WITH NON-INSULIN-DEPENDENT DIABETES-MELLITUS [J].
BRAUN, B ;
ZIMMERMANN, MB ;
KRETCHMER, N .
JOURNAL OF APPLIED PHYSIOLOGY, 1995, 78 (01) :300-306
[5]   Improvement of insulin sensitivity by short-term exercise training in hypertensive African American women [J].
Brown, MD ;
Moore, GE ;
Korytkowski, MT ;
McCole, SD ;
Hagberg, JM .
HYPERTENSION, 1997, 30 (06) :1549-1553
[6]   QUANTIFICATION OF THE RELATIVE IMPAIRMENT IN ACTIONS OF INSULIN ON HEPATIC GLUCOSE-PRODUCTION AND PERIPHERAL GLUCOSE-UPTAKE IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS [J].
CAMPBELL, PJ ;
MANDARINO, LJ ;
GERICH, JE .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1988, 37 (01) :15-21
[7]   PROLONGED INCREASE IN INSULIN-STIMULATED GLUCOSE-TRANSPORT IN MUSCLE AFTER EXERCISE [J].
CARTEE, GD ;
YOUNG, DA ;
SLEEPER, MD ;
ZIERATH, J ;
WALLBERGHENRIKSSON, H ;
HOLLOSZY, JO .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (04) :E494-E499
[8]   7 CONSECUTIVE DAYS OF EXERCISE LOWERS PLASMA-INSULIN RESPONSES TO AN ORAL GLUCOSE CHALLENGE IN SEDENTARY ELDERLY [J].
CONONIE, CC ;
GOLDBERG, AP ;
ROGUS, E ;
HAGBERG, JM .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1994, 42 (04) :394-398
[9]   Independent and additive effects of energy restriction and exercise on glucose and insulin concentrations in sedentary overweight men [J].
Cox, KL ;
Burke, V ;
Morton, AR ;
Beilin, LJ ;
Puddey, IB .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2004, 80 (02) :308-316
[10]   Calorie restriction increases muscle insulin action but not IRS-1-, IRS-2-, or phosphotyrosine-PI 3-kinase [J].
Davidson, RT ;
Arias, EB ;
Cartee, GD .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2002, 282 (02) :E270-E276