Neuronal migration in the adult brain: are we there yet?

被引:154
作者
Ghashghaei, H. Troy
Lai, Cary
Anton, E. S.
机构
[1] Univ N Carolina, Sch Med, Ctr Neurosci, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Sch Med, Dept Cell & Cell Physiol, Chapel Hill, NC 27599 USA
[3] N Carolina State Univ, Sch Vet Med, Dept Mol Biomed Sci, Raleigh, NC 27606 USA
[4] Scripps Res Inst, Mol & Integrat Neurosci Dept, La Jolla, CA 92037 USA
关键词
D O I
10.1038/nrn2074
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The generation and targeting of appropriate numbers and types of neurons to where they are needed in the brain is essential for the establishment, maintenance and modification of neural circuitry. This review aims to summarize the patterns, mechanisms and functional significance of neuronal migration in the postnatal brain, with an emphasis on the migratory events that persist in the mature brain.
引用
收藏
页码:141 / 151
页数:11
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共 172 条
[31]   Cellular basis of reduced cortical reelin expression in schizophrenia [J].
Eastwood, SL ;
Harrison, PJ .
AMERICAN JOURNAL OF PSYCHIATRY, 2006, 163 (03) :540-542
[32]   Hippocampus: Cognitive processes and neural representations that underlie declarative memory [J].
Eichenbaum, H .
NEURON, 2004, 44 (01) :109-120
[33]   α6β1 integrin directs migration of neuronal precursors in adult mouse forebrain [J].
Emsley, JG ;
Hagg, T .
EXPERIMENTAL NEUROLOGY, 2003, 183 (02) :273-285
[34]   Fluoxetine targets early progenitor cells in the adult brain [J].
Encinas, Juan M. ;
Vaahtokari, Anne ;
Enikolopov, Grigori .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (21) :8233-8238
[35]   Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination [J].
Enwere, E ;
Shingo, T ;
Gregg, C ;
Fujikawa, H ;
Ohta, S ;
Weiss, S .
JOURNAL OF NEUROSCIENCE, 2004, 24 (38) :8354-8365
[36]   Neurogenesis in the adult human hippocampus [J].
Eriksson, PS ;
Perfilieva, E ;
Björk-Eriksson, T ;
Alborn, AM ;
Nordborg, C ;
Peterson, DA ;
Gage, FH .
NATURE MEDICINE, 1998, 4 (11) :1313-1317
[37]   In vivo induction of massive proliferation, directed migration, and differentiation of neural cells in the adult mammalian brain [J].
Fallon, J ;
Reid, S ;
Kinyamu, R ;
Opole, I ;
Opole, R ;
Baratta, J ;
Korc, M ;
Endo, TL ;
Duong, A ;
Nguyen, G ;
Karkehabadhi, M ;
Twardzik, D ;
Loughlin, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (26) :14686-14691
[38]   Reelin glycoprotein in autism and schizophrenia [J].
Fatemi, SH .
GABA IN AUTISM AND RELATED DISORDERS, 2005, 71 :179-187
[39]   Neurogenesis and neuronal regeneration in the adult reptilian brain [J].
Font, E ;
Desfilis, E ;
Pérez-Cañellas, MM ;
García-Verdugo, JM .
BRAIN BEHAVIOR AND EVOLUTION, 2001, 58 (05) :276-295
[40]   Reelin, Disabled 1, and β1 integrins are required for the formation of the radial glial scaffold in the hippocampus [J].
Förster, E ;
Tielsch, A ;
Saum, B ;
Weiss, KH ;
Johanssen, C ;
Graus-Porta, D ;
Müller, U ;
Frotscher, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :13178-13183