Diseases of iron metabolism

被引:9
作者
Hagar, W
Theil, EC
Vichinsky, EP
机构
[1] Childrens Hosp Oakland, Dept Hematol Oncol, Oakland, CA 94609 USA
[2] Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USA
关键词
D O I
10.1016/S0031-3955(02)00028-7
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
This discussion follows the flow of iron from dietary intake, through absorption, to organ uptake, to cellular use, to release, and to iron re-uptake or loss. Known and putative diseases will be discussed at each step. Although discussed separately, these processes both occur simultaneously and influence each other. Like many other fields of cellular and molecular science, the challenge is both to reduce a complex problem to parts that can be studied and then to reassemble the parts into a clinically useful whole.
引用
收藏
页码:893 / +
页数:18
相关论文
共 78 条
[21]  
Edwards CQ, 1998, SEMIN HEMATOL, V35, P72
[22]   Pumping iron: the strange partnership of the hemochromatosis protein, a class I MHC homolog, with the transferrin receptor [J].
Enns, CA .
TRAFFIC, 2001, 2 (03) :167-174
[23]   MODULATION OF IRON-METABOLISM IN MONOCYTE CELL-LINE U937 BY INFLAMMATORY CYTOKINES - CHANGES IN TRANSFERRIN UPTAKE, IRON HANDLING AND FERRITIN MESSENGER-RNA [J].
FAHMY, M ;
YOUNG, SP .
BIOCHEMICAL JOURNAL, 1993, 296 :175-181
[24]   The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding [J].
Feder, JN ;
Penny, DM ;
Irrinki, A ;
Lee, VK ;
Lebrón, JA ;
Watson, N ;
Tsuchihashi, Z ;
Sigal, E ;
Bjorkman, PJ ;
Schatzman, RC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (04) :1472-1477
[25]   The hemochromatosis founder mutation in HLA-H disrupts beta(2)-microglobulin interaction and cell surface expression [J].
Feder, JN ;
Tsuchihashi, Z ;
Irrinki, A ;
Lee, VK ;
Mapa, FA ;
Morikang, E ;
Prass, CE ;
Starnes, SM ;
Wolff, RK ;
Parkkila, S ;
Sly, WS ;
Schatzman, RC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (22) :14025-14028
[26]   Early embryonic lethality of H ferritin gene deletion in mice [J].
Ferreira, C ;
Bucchini, D ;
Martin, ME ;
Levi, S ;
Arosio, P ;
Grandchamp, B ;
Beaumont, C .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (05) :3021-3024
[27]   H ferritin knockout mice:: a model of hyperferritinemia in the absence of iron overload [J].
Ferreira, C ;
Santambrogio, P ;
Martin, ME ;
Andrieu, V ;
Feldmann, G ;
Hénin, D ;
Beaumont, C .
BLOOD, 2001, 98 (03) :525-532
[28]   Overexpression of H ferritin and up-regulation of iron regulatory protein genes during differentiation of 3T3-L1 pre-adipocytes [J].
Festa, M ;
Ricciardelli, G ;
Mele, G ;
Pietropaolo, C ;
Ruffo, A ;
Colonna, A .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (47) :36708-36712
[29]  
FILLET G, 1989, BLOOD, V74, P844
[30]   Associations of iron overload in Africa with hepatocellular carcinoma and tuberculosis: Strachan's 1929 thesis revisited [J].
Gordeuk, VR ;
McLaren, CE ;
MacPhail, AP ;
Deichsel, G ;
Bothwell, TH .
BLOOD, 1996, 87 (08) :3470-3476