Conserved metabolic regulatory functions of sirtuins

被引：341

作者：

Schwer, Bjoern ^{[1
,2
]}

Verdin, Eric ^{[1
,2
]}

机构：

[1] Gladstone Inst Virol & Immunol, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

来源：

CELL METABOLISM | 2008年 / 7卷 / 02期

关键词：

D O I：

10.1016/j.cmet.2007.11.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases/mono-ADP-ribosyltransferases found in organisms ranging from bacteria to humans. Their dependence on nicotinamide adenine dinucleotide (NAD+) links their activity to cellular metabolic status. In bacteria, the sirtuin CobB regulates the metabolic enzyme acetyl-coenzyme A (acetyl-CoA) synthetase. The earliest function of sirtuins therefore may have been regulation of cellular metabolism in response to nutrient availability. Recent findings support the idea that sirtuins play a pivotal role in metabolic control in higher organisms, including mammals. This review surveys evidence for an emerging role of sirtuins as regulators of metabolism in mammals.

引用

页码：104 / 112

页数：9

共 82 条

[1] Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase [J].

Ahuja, Nidhi ;

Schwer, Bjoern ;

Carobbio, Stefania ;

Waltregny, David ;

North, Brian J. ;

Castronovo, Vincenzo ;

Maechler, Pierre ;

Verdin, Eric .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (46) :33583-33592

[2] Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae [J].

Anderson, RM ;

Bitterman, KJ ;

Wood, JG ;

Medvedik, O ;

Sinclair, DA .

NATURE, 2003, 423 (6936) :181-185

[3] Resveratrol improves health and survival of mice on a high-calorie diet [J].

Baur, Joseph A. ;

Pearson, Kevin J. ;

Price, Nathan L. ;

Jamieson, Hamish A. ;

Lerin, Carles ;

Kalra, Avash ;

Prabhu, Vinayakumar V. ;

Allard, Joanne S. ;

Lopez-Lluch, Guillermo ;

Lewis, Kaitlyn ;

Pistell, Paul J. ;

Poosala, Suresh ;

Becker, Kevin G. ;

Boss, Olivier ;

Gwinn, Dana ;

Wang, Mingyi ;

Ramaswamy, Sharan ;

Fishbein, Kenneth W. ;

Spencer, Richard G. ;

Lakatta, Edward G. ;

Le Couteur, David ;

Shaw, Reuben J. ;

Navas, Placido ;

Puigserver, Pere ;

Ingram, Donald K. ;

de Cabo, Rafael ;

Sinclair, David A. .

NATURE, 2006, 444 (7117) :337-342

[4] Therapeutic potential of resveratrol:: the in vivo evidence [J].

Baur, Joseph A. ;

Sinclair, David A. .

NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (06) :493-506

[5] Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+ [J].

Belenky, Peter ;

Racette, Frances G. ;

Bogan, Katrina L. ;

McClure, Julie M. ;

Smith, Jeffrey S. ;

Brenner, Charles .

CELL, 2007, 129 (03) :473-484

[6] Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast Sir2 and human SIRT1 [J].

Bitterman, KJ ;

Anderson, RM ;

Cohen, HY ;

Latorre-Esteves, M ;

Sinclair, DA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (47) :45099-45107

[7] The Sir2 family of protein deacetylases [J].

Blander, G ;

Guarente, L .

ANNUAL REVIEW OF BIOCHEMISTRY, 2004, 73 :417-435

[8] Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic β cells [J].

Bordone, L ;

Motta, MC ;

Picard, F ;

Robinson, A ;

Jhala, US ;

Apfeld, J ;

McDonagh, T ;

Lemieux, M ;

McBurney, M ;

Szilvasi, A ;

Easlon, EJ ;

Lin, SJ ;

Guarente, L .

PLOS BIOLOGY, 2006, 4 (02) :210-220

[9] Calorie restriction, SIRT1 and metabolism: Understanding longevity [J].

Bordone, L ;

Guarente, L .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (04) :298-305

[10] SIRT1 transgenic mice show phenotypes resembling calorie restriction [J].

Bordone, Laura ;

Cohen, Dena ;

Robinson, Ashley ;

Motta, Maria Carla ;

van Veen, Ed ;

Czopik, Agnieszka ;

Steele, Andrew D. ;

Crowe, Hayley ;

Marmor, Stephen ;

Luo, Jianyuan ;

Gu, Wei ;

Guarente, Leonard .

AGING CELL, 2007, 6 (06) :759-767

← 1 2 3 4 5 6 7 8 9 →