Differential pulse voltammetric determination of paracetamol at nanogold modified indium tin oxide electrode

被引：288

作者：

Goyal, RN ^{[1
]}

Gupta, VK

Oyama, M

Bachheti, N

机构：

[1] Indian Inst Technol, Dept Chem, Roorkee 247667, Uttar Pradesh, India

[2] Kyoto Univ, Div Res Initiat, Int Innovat Ctr, Sakyo Ku, Kyoto 6068501, Japan

来源：

ELECTROCHEMISTRY COMMUNICATIONS | 2005年 / 7卷 / 08期

基金：

日本学术振兴会;

关键词：

nanogold modified indium tin oxide electrode; paracetamol; differential pulse voltammetry; pharmaceutical preparations;

D O I：

10.1016/j.elecom.2005.05.005

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

A nanogold modified indium tin oxide (ITO) electrode was used for the determination of paracetamol at pH 7.2. The electrode exhibited an effective catalytic response to the oxidation of paracetamol with good reproducibility and stability. Under conditions of differential pulse voltammetry, the oxidation potential of paracetamol is lowered by approximately 110 mV and current response is enhanced significantly relative to the situation prevailing when a bare ITO electrode is used. Linear calibration curve is obtained over the range 2.0 x 10(-7)-1.5 x 10(-3) M with a correlation coefficient of 0.997. The detection limit (3 sigma) was estimated to be 1.8 x 10(-7) M. The physiologically common interferents viz., ascorbic acid, glucose and urea negligibly affected the current response of paracetamol. The practical analytical utility of the method is illustrated by determination of paracetamol in pharmaceutical preparations. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：803 / 807

页数：5

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