A review of biological factors implicated in abdominal aortic aneurysm rupture

被引:220
作者
Choke, E
Cockerill, G
Wilson, WRW
Sayed, S
Dawson, J
Loftus, I
Thompson, MM
机构
[1] Univ London St Georges Hosp, Dept Vasc Surg, Sch Med, London SW17 0QT, England
[2] Leicester Royal Infirm, Dept Vasc Surg, Leicester, Leics, England
关键词
abdominal aortic aneurysm; rupture; matrix metalloproteinase; enzyme; collagen;
D O I
10.1016/j.ejvs.2005.03.009
中图分类号
R61 [外科手术学];
学科分类号
摘要
Abdominal aortic aneurysm (AAA) rupture is the 13th commonest cause of death in the Western World. Although considerable research has been applied to the aetiology and mechanism of aneurysm expansion, little is known about the mechanism of rupture. Aneurysm rupture was historically considered to be a simple physical process that occurred when the aortic wall could no longer contain the haemodynamic stress of the circulation. However, AAAs do not conform to the law of Laplace and there is growing evidence that aneurysm rupture involves a complex series of biological changes in the aortic wall. This paper reviews the available data on patient variables associated with aneurysm rupture and presents the evidence implicating biological factors in AAA rupture.
引用
收藏
页码:227 / 244
页数:18
相关论文
共 191 条
[1]  
ACINAPURA AJ, 1987, J CARDIOVASC SURG, V28, P552
[2]   Cellular content and permeability of intraluminal thrombus in abdominal aortic aneurysm [J].
Adolph, R ;
Vorp, DA ;
Steed, DL ;
Webster, MW ;
Kameneva, MV ;
Watkins, SC .
JOURNAL OF VASCULAR SURGERY, 1997, 25 (05) :916-926
[3]   Current concepts in the pathogenesis of abdominal aortic aneurysm [J].
Ailawadi, G ;
Eliason, JL ;
Upchurch, GR .
JOURNAL OF VASCULAR SURGERY, 2003, 38 (03) :584-588
[4]  
ALBINA JE, 1995, J IMMUNOL, V155, P4391
[5]   Local overexpression of TIMP-1 prevents aortic aneurysm degeneration and rupture in a rat model [J].
Allaire, E ;
Forough, R ;
Clowes, W ;
Starcher, B ;
Clowes, AW .
JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (07) :1413-1420
[6]   Prevention of aneurysm development and rupture by local overexpression of plasminogen activator inhibitor-1 [J].
Allaire, E ;
Hasenstab, D ;
Kenagy, RD ;
Starcher, B ;
Clowes, MM ;
Clowes, AW .
CIRCULATION, 1998, 98 (03) :249-255
[7]  
Anderton M, 2002, BRIT J SURG, V89, P33
[8]  
Anderton M, 2002, BRIT J SURG, V89, P15
[9]   CORRELATION OF INFLAMMATORY INFILTRATE WITH THE ENLARGEMENT OF EXPERIMENTAL AORTIC-ANEURYSMS [J].
ANIDJAR, S ;
DOBRIN, PB ;
EICHORST, M ;
GRAHAM, GP ;
CHEJFEC, G .
JOURNAL OF VASCULAR SURGERY, 1992, 16 (02) :139-147
[10]   Differential regulation of matrix metalloproteinase activities in abdominal aortic aneurysms [J].
Annabi, B ;
Shédid, D ;
Ghosn, P ;
Kenigsberg, RL ;
Desrosiers, RR ;
Bojanowski, MW ;
Beaulieu, É ;
Nassif, E ;
Moumdjian, R ;
Béliveau, R .
JOURNAL OF VASCULAR SURGERY, 2002, 35 (03) :539-546