Neurobiology with caged calcium

被引：115

作者：

Ellis-Davies, Graham C. R. ^{[1
]}

机构：

[1] Drexel Univ, Dept Physiol & Pharmacol, Coll Med, Philadelphia, PA 19102 USA

来源：

CHEMICAL REVIEWS | 2008年 / 108卷 / 05期

关键词：

D O I：

10.1021/cr078210i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A review on the wide variety of cells and cellular functions regulated by ionized calcium (Ca2+) is given as well as the history of the development of caged Ca2+ molecules referring to the requirements of the experimental application of each photosensitive probe. The term "caged" is defined to be the functional encapsulation of a chemical messenger in a biologically inert and photosensitive form. Specific topics include: on what does Ca2+ inside cells; the key biological applications of caged Ca2+; and finally, the two-photon uncaging of Ca2+ in living cells.

引用

页码：1603 / 1613

页数：11

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