Recent progress in cartilage tissue engineering

被引：117

作者：

Keeney, Michael ^{[1
]}

Lai, Janice H. ^{[2
]}

Yang, Fan ^{[1
,3
]}

机构：

[1] Stanford Univ, Dept Orthopaed Surg, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Mech Engn, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2011年 / 22卷 / 05期

关键词：

MESENCHYMAL STEM-CELLS; ARTICULAR-CARTILAGE; CHONDROGENIC DIFFERENTIATION; CHONDROITIN SULFATE; POROUS SCAFFOLD; REGENERATION; HYDROGELS; CHONDROCYTES; INTEGRATION; COLLAGEN;

D O I：

10.1016/j.copbio.2011.04.003

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

Despite over two decades of research on cartilage tissue engineering, very few products have moved from bench to bedside and effective therapy remains lacking. This review discusses recent progress in developing novel strategies for engineering cartilage tissues with long-term functionality. Specifically we focus on the following aspects including identifying promising cell sources, designing 3D scaffolds with dynamic and spatially patterned cues to guide desired cellular processes, mimicking zonal organization, integrating with host tissue, and monitoring cell fate and tissue regeneration in situ.

引用

页码：734 / 740

页数：7

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