Animal models of Alzheimer's disease and frontotemporal dementia

被引：508

作者：

Gotz, Jurgen ^{[1
]}

Ittner, Lars M. ^{[1
]}

机构：

[1] Univ Sydney, Brain & Mind Res Inst, Alzheimers & Parkinsons Dis Lab, Camperdown, NSW 2050, Australia

来源：

NATURE REVIEWS NEUROSCIENCE | 2008年 / 9卷 / 07期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

D O I：

10.1038/nrn2420

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Insoluble protein aggregates have been linked to Alzheimer's disease (AD) and frontotemporal dementia (FTD). Recent work in transgenic mice has shed light on the role of these aggregates by identifying soluble oligomeric species that may interfere with essential cellular mechanisms at an early disease stage. This review summarizes what we have learned about the roles of these proteins from transgenic mice and invertebrate species such as flies and worms. Proteomic and transcriptomic analyses of tissue from these animal models have identified new molecules with crucial roles in disease. Moreover, transgenic animals have been instrumental in defining drug targets and designing novel therapeutic strategies. With advanced imaging techniques that can be used in both humans and mice an early, preclinical diagnosis of AD and FTD could be within reach.

引用

页码：532 / 544

页数：13

共 169 条

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