FLT3/D835 mutation and inversion of chromosome 16 in leukemic transformation of myelofibrosis

被引：5

作者：

Colovic, Milica

Jurisic, Vladimir ^{[1
]}

Pavlovic, Sonja

Terzic, TaIjana

Colovic, Natasa

机构：

[1] Univ Kragujevac, Sch Med, Kragujevac, Serbia

[2] Univ Clin Ctr, Inst Hematol, Belgrade, Serbia

[3] Inst Mol Genet & Genet Engn, Belgrade 11001, Serbia

[4] Inst Pathol, Belgrade, Serbia

来源：

EUROPEAN JOURNAL OF INTERNAL MEDICINE | 2006年 / 17卷 / 06期

关键词：

FLT-3; mutation; D835 point mutation; Inv16; myelofibrosis; leukemic transformation; diffuse osteolyses; TNF-alpha;

D O I：

10.1016/j.ejim.2006.02.028

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

We present an atypical case of myelofibrosis developing into secondary leukemia FAB subtype M4, with inversion of chromosome 16, FLT3/D835 point mutation and diffuse osteolytic lesions accompanied by elevated TNF-alpha. The simultaneous occurrence of these mutations reflects the progressive association of genetic lesions developing into secondary leukemia with a relatively benign course. (C) 2006 European Federation of Internal Medicine. Published by Elsevier B.V.

引用

页码：434 / 435

页数：2

共 6 条

[1]

Mutational analysis of class III receptor tyrosine kinases (C-KIT, C-FMS, FLT3) in idiopathic myelofibrosis [J].