Effect of Apelin in Cardiovascular System and Water Metabolism

被引：1

作者：

Corvol, Pierre ^{[1
]}

机构：

[1] Coll France, INSERM, U833, F-75005 Paris, France

来源：

THERAPIE | 2009年 / 64卷 / 04期

关键词：

angiogenesis; cardiovascular development; renin angiotensin system; vasopressin; IN-VIVO; DEFICIENT MICE; HEART-FAILURE; RECEPTOR; ANGIOGENESIS; GENE; APJ; CONTRACTILITY; VASOPRESSIN;

D O I：

10.2515/therapie/2009045

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Effect of Apelin in Cardiovascular System and Water Metabolism. Apelin is a recently identified peptide which plays an important role in cardiovascular function and in water metabolism. Apelin and its receptor APJ (apelin system) are involved in zebra fish and xenopus cardiovascular development. Apelin is a pro-angiogenic factor. Apelin is a potent cardiac inotropic agent and exerts a vasodilatory effect in arterial and venous territories. Apelin decreases vasopressin production and its plasma level is conversely related to plasma vasopressin. Several effects of the apelin system counteract those of the renin angiotensin system. It may represent a new and promising therapeutic opportunity for the treatment of cardiovascular diseases.

引用

页码：233 / 239

页数：7

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