Lewis base-catalyzed three-component Strecker reaction on water. An efficient manifold for the direct α-cyanoamination of ketones and aldehydes

被引：44

作者：

Cruz-Acosta, Fabio ^{[1
,2
]}

Santos-Exposito, Alicia ^{[1
]}

de Armas, Pedro ^{[1
,2
]}

Garcia-Tellado, Fernando ^{[1
,2
]}

机构：

[1] CSIC, Dept Quim Biol & Biotecnol, Inst Prod Nat & Agrobiol, San Cristobal la Laguna 38206, Spain

[2] Inst Canario Invest Canc, San Cristobal la Laguna, Spain

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 44期

关键词：

ONE-POT SYNTHESIS; AMINO-ACIDS; TRIBUTYLTIN CYANIDE; FLUORINATED ANALOGS; ACYL CYANIDES; METAL-FREE; AMINONITRILES; CYANATION; KETIMINES;

D O I：

10.1039/b914151k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first three-component organocatalyzed Strecker reaction operating on water has been developed. The manifold utilizes ketones (aldehydes) as the starting carbonyl component, aniline as the primary amine, acetyl cyanide as the cyanide source and N,N-dimethylcyclohexylamine as the catalyst.

引用

页码：6839 / 6841

页数：3

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