Solvent-free synthesis of racemic α-aminonitriles

被引：48

作者：

Baeza, Alejandro ^{[1
]}

Najera, Carmen ^{[1
]}

Sansano, Jose M. ^{[1
]}

机构：

[1] Univ Alicante, Fac Ciencias, Dept Quim Organ, Alicante 03080, Spain

来源：

SYNTHESIS-STUTTGART | 2007年 / 08期

关键词：

addition reactions; Strecker synthesis; catalysis; aminonitriles; green chemistry; solvent-free;

D O I：

10.1055/s-2007-965974

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A very simple one-step, environmentally friendly procedure for the synthesis of alpha-aminonitriles from aldehydes and ketones, using trimethylsilyl cyanide in the absence of solvent, is reported. The active catalyst of this three-component (Strecker) reaction was the amine employed in the transformation. In general, aldehydes react more rapidly than ketones and give almost quantitative yields of the corresponding alpha-aminonitriles in less than fifteen minutes. However, only cyclic ketones afford the corresponding a-aminonitriles in excellent chemical yields under these conditions.

引用

收藏

页码：1230 / 1234

页数：5

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