The oxygen-binding vs. oxygen-consuming paradigm in biocatalysis: structural biology and biomolecular simulation

被引：31

作者：

Baron, Riccardo ^{[1
,2
]}

McCammon, J. Andrew ^{[1
,2
,3
,4
]}

Mattevi, Andrea ^{[5
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Ctr Theoret Biol Phys, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Howard Hughes Med Inst, La Jolla, CA 92093 USA

[5] Univ Pavia, Dept Genet & Microbiol, I-27100 Pavia, Italy

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2009年 / 19卷 / 06期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

X-RAY CRYSTALLOGRAPHY; CYTOCHROME-C-OXIDASE; MOLECULAR-DYNAMICS; MIGRATION PATHWAYS; ELECTRON-TRANSFER; LIGAND MIGRATION; O-2; SITE; IDENTIFICATION; INTERMEDIATE;

D O I：

10.1016/j.sbi.2009.10.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxygen biocatalysis and regulation is crucial to a variety of biochemical processes in nature. Oxygen-binding proteins cover only a limited part of oxygen biocatalysis, which involves numerous examples of oxygen-consuming biocatalysts with low oxygen affinities. The integration of experiments with powerful biomolecular simulation opens appealing possibilities to investigate crucial questions on the fascinating relationship between enzyme dynamics and oxygen biocatalysis in new protein structures.

引用

页码：672 / 679

页数：8

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