Ultra-performance liquid chromatography coupled to time of flight mass spectrometry (UPLC-TOF): A novel tool for multiresidue screening of veterinary drugs in urine

被引：114

作者：

Kaufmann, Anton ^{[1
]}

Butcher, Patrick ^{[1
]}

Maden, Kathryn ^{[1
]}

Widmer, Mirjam ^{[1
]}

机构：

[1] Official Food Control Author Canton Zurich Kanton, CH-8030 Zurich, Switzerland

来源：

ANALYTICA CHIMICA ACTA | 2007年 / 586卷 / 1-2期

关键词：

screening; veterinary drugs; ultra-performance liquid chromatography (UPLC); time of flight mass spectrometry (TOF); multiresidue;

D O I：

10.1016/j.aca.2006.10.026

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A multiresidue method for the screening of veterinary drugs in urine with ultra-performance liquid chromatography (UPLC) coupled to time of flight mass spectrometry (TOF) is proposed. The method covers currently more than 100 analytes belonging to different families of veterinary drugs. Urine samples are simply diluted and injected unfiltered into the UPLC-TOF The short run time permit high-throughput of large series under a routine environment. The suggested approach includes the detection of some metabolites which are relevant to the urine matrix. The paper discusses the usefulness of metabolites as additional confirmation criteria for positive findings and suggests a revisiting of the identification point system in the light of additional resolution, as provided by the TOF and the UPLC technology. The proposed multiresidue approach was further broadened by monitoring drug group specific collision induced fragments (CID). Examples show the monitoring of generic CID fragments typical for sulfonamides and penicillines. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：13 / 21

页数：9

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