Betulinic acid: Isolation from Triphyophyllum peltatum and Ancistrocladus heyneanus, antimalarial activity, and crystal structure of the benzyl ester

被引：114

作者：

Bringmann, G

Saeb, W

Assi, LA

Francois, G

Narayanan, ASS

Peters, K

Peters, EM

机构：

[1] UNIV ABIDJAN,CTR NATL FLORIST,ABIDJAN 08,COTE IVOIRE

[2] INST TROP MED PRINCE LEOPOLD,B-2000 ANTWERP,BELGIUM

[3] NATIVE MEDICARE CHARITABLE TRUST,COIMBATORE 641108,TAMIL NADU,INDIA

[4] MAX PLANCK INST FESTKORPERFORSCH,D-70506 STUTTGART,GERMANY

来源：

PLANTA MEDICA | 1997年 / 63卷 / 03期

关键词：

Triphyophyllum peltatum; Ancistrocladus heyneanus; Dioncophyllaceae; Ancistrocladaceae; triterpenes; betulinic acid; antimalarial activity; Plasmodium falciparum; crystal structure;

D O I：

10.1055/s-2006-957666

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The known lupane-type triterpene betulinic acid (3) was isolated for the first time from Triphyophyllum peltatum and Ancistroclados heyneanus, It was found to exhibit moderate to good in vitro antimalarial activity against asexual erythrocytic stages of the human malaria parasite Plasmodium falciparum, A first X-ray structure analysis succeeded after conversion into its benzyl ester 4.

引用

页码：255 / 257

页数：3

共 23 条

[11]

HEGNAUER R, 1989, CHEMOTAXONOMIE PFLAN, V8, P388

[12]

LIU S, 1984, J STRUCT CHEM, V3, P225

[13] DISCOVERY OF BETULINIC ACID AS A SELECTIVE INHIBITOR OF HUMAN-MELANOMA THAT FUNCTIONS BY INDUCTION OF APOPTOSIS [J].

PISHA, E ;

CHAI, H ;

LEE, IS ;

CHAGWEDERA, TE ;

FARNSWORTH, NR ;

CORDELL, GA ;

BEECHER, CWW ;

FONG, HHS ;

KINGHORN, AD ;

BROWN, DM ;

WANI, MC ;

WALL, ME ;

HIEKEN, TJ ;

DASGUPTA, TK ;

PEZZUTO, JM .

NATURE MEDICINE, 1995, 1 (10) :1046-1051

[14]

RECIO MD, 1995, PLANTA MED, V61, P9, DOI 10.1055/s-2006-957988

[15] TRADITIONAL MEDICINAL-PLANTS OF THAILAND .5. ANCISTROTECTORINE, A NEW NAPHTHALENE-ISOQUINOLINE ALKALOID FROM ANCISTROCLADUS-TECTORIUS [J].

RUANGRUNGSI, N ;

WONGPANICH, V ;

TANTIVATANA, P ;

COWE, HJ ;

COX, PJ ;

FUNAYAMA, S ;

CORDELL, GA .

JOURNAL OF NATURAL PRODUCTS, 1985, 48 (04) :529-535

[16]

Sauvain M, 1996, PHYTOTHER RES, V10, P1, DOI 10.1002/(SICI)1099-1573(199602)10:1&lt

[17]

1::AID-PTR757&gt

[18]

3.0.CO

[19]

2-A

[20] TUMOR-INHIBITORY AGENT FROM HYPTIS-EMORYI (LABIATAE) [J].

SHETH, K ;

WIEDHOPF, R ;

JOLAD, S ;

COLE, JR .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1972, 61 (11) :1819-&

← 1 2 3 →