Redox regulation of stem cell mobilization

被引：16

作者：

Lekli, Istvan ^{[1
]}

Gurusamy, Narasimman ^{[1
]}

Ray, Diptarka ^{[1
]}

Tosaki, Arpad ^{[2
]}

Das, Dipak K. ^{[1
]}

机构：

[1] Univ Connecticut, Sch Med, Cardiovasc Res Ctr, Farmington, CT 06030 USA

[2] Univ Debrecen, Sch Pharm, Dept Pharmacol, H-4012 Debrecen, Hungary

来源：

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 2009年 / 87卷 / 12期

关键词：

hematopoietic stem cells; HIF-1; alpha; FoxO; SirT; redox signaling; stem cell homing; cytokines; HEMATOPOIETIC PROGENITOR CELLS; OXIDATIVE STRESS; BONE-MARROW; PERIPHERAL-BLOOD; ADHESION MOLECULES; NADPH OXIDASE; OXYGEN; P53; DIFFERENTIATION; HYPOXIA;

D O I：

10.1139/Y09-102

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A growing body of evidence supports the role of redox signaling in the mechanisms of hematopoietic stem cell mobilization and homing. Cytokines and adhesion molecules control stem cell mobilization through a redox-regulated process. The FoxO-SirT network appears to be intimately involved in redox-regulated stem cell homeostasis, whereas the process of stem cell differentiation is regulated by redox effector factor-1 (Ref-1) protein. Lack of oxygen (hypoxia), specifically controlled hypoxia, can stimulate the growth of the stem cells in their niche, and hypoxia-inducible factor (HIF)-1 alpha appears to play a significant role in their maintenance and homing mechanism.

引用

页码：989 / 995

页数：7

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