Convergent synthesis of dihydroquinolones from o-aminoarylboronates

被引:36
作者
Horn, Joachim [1 ]
Li, Ho Yin [1 ]
Marsden, Stephen P. [1 ]
Nelson, Adam [1 ]
Shearer, Rachel J. [1 ]
Campbell, Amanda J. [2 ]
House, David [2 ]
Weingarten, Gordon G. [2 ]
机构
[1] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England
[2] GlaxoSmithKline Inc, Med Res Ctr, Stevenage SG1 2NY, Herts, England
基金
英国工程与自然科学研究理事会;
关键词
7-MEMBERED RING LACTAMS; REGIOSPECIFIC SYNTHESIS; RADICAL CYCLIZATION; ARYLBORONIC ACIDS; DERIVATIVES; CYCLOCARBONYLATION; 1,4-ADDITION; METALATION; QUINOLINE; LACTONES;
D O I
10.1016/j.tet.2009.06.103
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An efficient and convergent one-step synthesis of substituted dihydroquinolin-2-ones from alpha,beta-unsaturated esters and aminoaryl pinacolboronates under rhodium catalysis is reported. The reaction is easily applicable in parallel synthesis format and provides convenient access to this pharmaceutically-relevant motif. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:9002 / 9007
页数:6
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