Synthesis and biological activity of the (-)-(2R,3S,4S)-3-azido-4-methoxy-2-(1′S-methoxy-2′-azido)ethyl-thiolane

被引：10

作者：

Arcelli, A

Cerè, V

Peri, F

Pollicino, S

Sabatino, P

机构：

[1] Univ Bologna, Dipartimento Chim Organ A Mangini, I-40136 Bologna, Italy

[2] Univ Bologna, Dipartimento Chim G Ciamician, I-40126 Bologna, Italy

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 06期

关键词：

D O I：

10.1016/S0957-4166(00)00071-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A stereospecific ring contraction reaction, promoted by NaN3, was detected starting from a thiepane derivative obtained from D-sorbitol, an inexpensive alcohol sugar. The major polyfunctionalized thiolane derivative obtained was investigated as a potential glycosidase inhibitor. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.

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页码：1389 / 1395

页数：7

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