Copper, iron, and zinc ions homeostasis and their role in neurodegenerative disorders (metal uptake, transport, distribution and regulation)

被引：408

作者：

Kozlowski, Henryk ^{[1
]}

Janicka-Klos, Anna ^{[2
]}

Brasun, Justyna ^{[2
]}

Gaggelli, Elena ^{[3
]}

Valensin, Daniela ^{[3
]}

Valensin, Gianni ^{[3
]}

机构：

[1] Univ Wroclaw, Fac Chem, PL-50383 Wroclaw, Poland

[2] Silesian Piasts Univ Med Wroclaw, Fac Pharm, Dept Inorgan Chem, PL-50139 Wroclaw, Poland

[3] Univ Siena, Dept Chem, I-53100 Siena, Italy

来源：

COORDINATION CHEMISTRY REVIEWS | 2009年 / 253卷 / 21-22期

关键词：

Copper; Iron; Zinc; Metal homeostasis; Metal transport; Regulation of metals; Diseases affected by metals; AMYLOID-PRECURSOR-PROTEIN; A-BETA PEPTIDE; ALZHEIMERS-DISEASE; CRYSTAL-STRUCTURE; OXIDATIVE STRESS; PRION PROTEIN; SUPEROXIDE-DISMUTASE; BRAIN IRON; CU; ZN-SUPEROXIDE DISMUTASE; MESSENGER-RNA;

D O I：

10.1016/j.ccr.2009.05.011

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Metal ions, especially with high chemical activity (e.g. redox-active Cu and Fe) must be carefully managed in biological systems. The "uncontrolled" activity, e.g. catalysis of Fenton-like reactions by ions like Cu(I) or Fe(II), is so damaging for the biological milieu that right from their entry, metal ions need to be strictly controlled until they arrive at their storage site. This chaperoning occurs usually by proteins which are involved in transport, delivery and distribution processes. In this review some aspects of the metal homeostasis for major metal ions (Cu, Fe, and Zn) are presented. The impact of these metals on some disorders are also discussed. (C) 2009 Elsevier B.V. All rights reserved.

引用

收藏

页码：2665 / 2685

页数：21

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