Gain-of-function mutagenesis of a modular polyketide synthase

被引:59
作者
McDaniel, R
Kao, CM
Fu, H
Hevezi, P
Gustafsson, C
Betlach, M
Ashley, G
Cane, DE
Khosla, C
机构
[1] STANFORD UNIV,DEPT CHEM ENGN,STANFORD,CA 94305
[2] STANFORD UNIV,DEPT CHEM,STANFORD,CA 94305
[3] STANFORD UNIV,DEPT BIOCHEM,STANFORD,CA 94305
[4] BROWN UNIV,DEPT CHEM,PROVIDENCE,RI 02912
关键词
D O I
10.1021/ja9702531
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:4309 / 4310
页数:2
相关论文
共 19 条
[1]  
AGOURIDAS C, 1995, 35 INT C ANT AG CHEM
[2]   A functional chimeric modular polyketide synthase generated via domain replacement [J].
Bedford, D ;
Jacobsen, JR ;
Luo, GL ;
Cane, DE ;
Khosla, C .
CHEMISTRY & BIOLOGY, 1996, 3 (10) :827-831
[3]   A MUTANT GENERATED BY EXPRESSION OF AN ENGINEERED DEBS1 PROTEIN FROM THE ERYTHROMYCIN-PRODUCING POLYKETIDE SYNTHASE (PKS) IN STREPTOMYCES-COELICOLOR PRODUCES THE TRIKETIDE AS A LACTONE, BUT THE MAJOR PRODUCT IS THE NOR-ANALOG DERIVED FROM ACETATE AS STARTER ACID [J].
BROWN, MJB ;
CORTES, J ;
CUTTER, AL ;
LEADLAY, PF ;
STAUNTON, J .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1995, (15) :1517-1518
[4]   AN UNUSUALLY LARGE MULTIFUNCTIONAL POLYPEPTIDE IN THE ERYTHROMYCIN-PRODUCING POLYKETIDE SYNTHASE OF SACCHAROPOLYSPORA-ERYTHRAEA [J].
CORTES, J ;
HAYDOCK, SF ;
ROBERTS, GA ;
BEVITT, DJ ;
LEADLAY, PF .
NATURE, 1990, 348 (6297) :176-178
[5]   REPOSITIONING OF A DOMAIN IN A MODULAR POLYKETIDE SYNTHASE TO PROMOTE SPECIFIC CHAIN CLEAVAGE [J].
CORTES, J ;
WIESMANN, KEH ;
ROBERTS, GA ;
BROWN, MJB ;
STAUNTON, J ;
LEADLAY, PF .
SCIENCE, 1995, 268 (5216) :1487-1489
[6]   AN ERYTHROMYCIN ANALOG PRODUCED BY REPROGRAMMING OF POLYKETIDE SYNTHESIS [J].
DONADIO, S ;
MCALPINE, JB ;
SHELDON, PJ ;
JACKSON, M ;
KATZ, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (15) :7119-7123
[7]   MODULAR ORGANIZATION OF GENES REQUIRED FOR COMPLEX POLYKETIDE BIOSYNTHESIS [J].
DONADIO, S ;
STAVER, MJ ;
MCALPINE, JB ;
SWANSON, SJ ;
KATZ, L .
SCIENCE, 1991, 252 (5006) :675-679
[8]   3-keto-11,12-carbazate derivatives of 6-O-methylerythromycin A synthesis and in vitro activity [J].
Griesgraber, G ;
Or, YS ;
Chu, DTW ;
Nilius, AM ;
Johnson, PM ;
Flamm, RK ;
Henry, RF ;
Plattner, JJ .
JOURNAL OF ANTIBIOTICS, 1996, 49 (05) :465-477
[9]   REPEATED POLYKETIDE SYNTHASE MODULES INVOLVED IN THE BIOSYNTHESIS OF A HEPTAENE MACROLIDE BY STREPTOMYCES SP FR-008 [J].
HU, ZH ;
BAO, K ;
ZHOU, XF ;
ZHOU, Q ;
HOPWOOD, DA ;
KIESER, T ;
DENG, ZX .
MOLECULAR MICROBIOLOGY, 1994, 14 (01) :163-172
[10]   ENGINEERED BIOSYNTHESIS OF A COMPLETE MACROLACTONE IN A HETEROLOGOUS HOST [J].
KAO, CM ;
KATZ, L ;
KHOSLA, C .
SCIENCE, 1994, 265 (5171) :509-512