Acute clinical hepatitis by immune restoration in a human immunodeficiency virus/hepatitis B virus co-infected patient receiving antiretroviral therapy

被引：11

作者：

Rouanet, I

Peyrière, H

Mauboussin, JM

Terrail, N

Vincent, D

机构：

[1] Hop G Doumergue, Serv Med Interne A Pneumol, F-30000 Nimes, France

[2] CHU Montpellier, Lapeyronie Hosp, Pharmacovigilance Ctr, Montpellier, France

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 2003年 / 15卷 / 01期

关键词：

HIV; hepatitis B; HAART; immune reconstitution;

D O I：

10.1097/00042737-200301000-00017

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We describe a human immunodeficiency virus (HIV)-infected patient with chronic active hepatitis B. The patient presented with acute clinical hepatitis during highly active antiretroviral therapy concomitant with immunovirological improvement of HIV infection. The hepatitis resolved within a few weeks despite the pursuit of antiretroviral drugs. Hepatitis B tests, which remained unchanged after two cycles of interferon alfa therapy and continuous administration of lamivudine, were improved with the clearance of hepatitis B virus (HBV) early antigen (HBeAg), the detection of antibody to HBV early antigen (HBeAb) and the undetectability of serum HBV DNA. Several months after this episode, HBV and HIV tests are still controlled. (C) 2003 Lippincott Williams Wilkins.

引用

页码：95 / 97

页数：3

共 7 条

[1] Chronic active hepatitis B exacerbations in human immunodeficiency virus-infected patients following development of resistance to or withdrawal of lamivudine [J].