Primary Skin Abscesses Are Mainly Caused by Panton-Valentine Leukocidin-Positive Staphylococcus aureus Strains

被引:45
作者
del Giudice, Pascal [1 ]
Blanc, Veronique [2 ]
de Rougemont, Alexis [3 ,4 ]
Bes, Michele [3 ,4 ]
Lina, Gerard [3 ,4 ]
Hubiche, Thomas [1 ]
Roudiere, Laurent [1 ]
Vandenesch, Francois [3 ,4 ]
Etienne, Jerome [3 ,4 ]
机构
[1] Hop Bonnet, Unite Malad Infect & Dermatol, Unit Infectol Dermatol, FR-83700 Frejus, France
[2] Ctr Hosp Antibes Juan les Pins, Antibes, France
[3] Univ Lyon 1, Ctr Natl Reference Staphylocoques, F-69365 Lyon, France
[4] Hosp Civils Lyon, Ctr Biol Est, Bron, France
关键词
Staphylococcus aureus; Panton-Valentine leukocidin; Abscess; Staphylococcal skin infection; Skin infection; METHICILLIN-RESISTANT STRAINS; VIRULENCE DETERMINANT; CUTANEOUS INFECTIONS; DISEASE; TOXINS; GENES; IDENTIFICATION; FURUNCLES; CARRIAGE; IMPETIGO;
D O I
10.1159/000232391
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: The role of Panton-Valentine leukocidin (PVL) in skin and soft-tissue infections is not clear. Objective: Our purpose was to determine the prevalence of PVL gene carriage among Staphylococcus aureus strains isolated from primary and secondary skin abscesses. Methods: A prospective study was conducted. From July 2003 to June 2008, S. aureus isolates from skin abscesses were screened for the PVL genes. The abscesses were considered primary if they occurred on previously healthy skin and secondary in all other cases. Results: Fifty-seven patients presenting with S. aureus skin abscesses were included in the study. The PVL genes were detected in 40 (70%) of the 57 S. aureus isolates. Thirty-eight (92.7%) of the 41 primary skin abscesses were due to PVL-positive strains, compared to only 2 (12.5%) of the 16 secondary skin abscesses (p < 0.001). Conclusions: Primary skin abscesses are mainly caused by PVL-positive S. aureus strains. Copyright (C) 2009 S. Karger AG, Basel
引用
收藏
页码:299 / 302
页数:4
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