Polycomb group proteins: navigators of lineage pathways led astray in cancer

被引：468

作者：

Bracken, Adrian P. ^{[1
,2
]}

Helin, Kristian ^{[3
,4
]}

机构：

[1] Univ Dublin Trinity Coll, Smurfit Inst Genet, Dublin 2, Ireland

[2] Natl Childrens Hosp, Adelaide & Meath Hosp, Dublin, Ireland

[3] Univ Copenhagen, BRIC, DK-22009 Copenhagen, Denmark

[4] Univ Copenhagen, Ctr Epigenet, DK-22009 Copenhagen, Denmark

来源：

NATURE REVIEWS CANCER | 2009年 / 9卷 / 11期

基金：

英国医学研究理事会; 新加坡国家研究基金会;

关键词：

TUMOR-SUPPRESSOR GENE; CELL SELF-RENEWAL; GENOME-WIDE ANALYSIS; LONG NONCODING RNAS; ZINC-FINGER GENE; TRANSCRIPTION FACTOR; TRANSGENIC MICE; BREAST-CANCER; C/EBP-ALPHA; STEM-CELLS;

D O I：

10.1038/nrc2736

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Polycomb group (PcG) proteins are transcriptional repressors that regulate lineage choices during development and differentiation. Recent studies have advanced our understanding of how the PcG proteins regulate cell fate decisions and how their deregulation potentially contributes to cancer. In this Review we discuss the emerging roles of long non-coding RNAs (ncRNAs) and a subset of transcription factors, which we call cell fate transcription factors, in the regulation of PcG association with target genes. We also speculate about how their deregulation contributes to tumorigenesis.

引用

页码：773 / 784

页数：12

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