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The retinoblastoma tumour suppressor in development and cancer

被引：594
作者：
Classon, M
Harlow, E
机构：
[1] MGH Canc Ctr, Boston, MA 02129 USA
[2] Harvard Univ, Sch Med, Boston, MA 02115 USA
来源：
NATURE REVIEWS CANCER | 2002年 / 2卷 / 12期
关键词：
D O I：
10.1038/nrc950
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 [肿瘤学];
摘要：
Since its discovery, the retinoblastoma (RB) tumour-suppressor protein has been a focal point of cancer research. Accumulating evidence indicates a complex role for RB in cell proliferation, differentiation and survival. To further complicate matters, proteins that are related to RB have redundant as well, as antagonistic functions. Recent studies of knockout mice and cells that lack one or more of these proteins have begun to clarify their various context-specific functions and the unique activity of this tumour suppressor.
引用
收藏
页码：910 / 917
页数：8
相关论文
共 130 条
[1]
THE RETINOBLASTOMA SUSCEPTIBILITY GENE-PRODUCT REPRESSES TRANSCRIPTION WHEN DIRECTLY BOUND TO THE PROMOTER [J].
ADNANE, J ;
SHAO, ZH ;
ROBBINS, PD .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (15) :8837-8843
[2]
DNA replication control through interaction of E2F-RB and the origin recognition complex [J].
Bosco, G ;
Du, W ;
Orr-Weaver, TL .
NATURE CELL BIOLOGY, 2001, 3 (03) :289-295
[3]
C-elegans class B synthetic multivulva genes act in G1 regulation [J].
Boxem, M ;
van den Heuvel, S .
CURRENT BIOLOGY, 2002, 12 (11) :906-911
[4]
Boxem M, 2001, DEVELOPMENT, V128, P4349
[5]
Retinoblastoma protein meets chromatin [J].
Brehm, A ;
Kouzarides, T .
TRENDS IN BIOCHEMICAL SCIENCES, 1999, 24 (04) :142-145
[6]
BREMNER R, 1995, MOL CELL BIOL, V15, P3256
[7]
Hyperuricemia in psoriatic arthritis - Prevalence and associated features [J].
Bruce, IN ;
Schentag, CT ;
Gladman, DD .
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, 2000, 6 (01) :6-9
[8]
Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after γ-irradiation [J].
Brugarolas, J ;
Moberg, K ;
Boyd, SD ;
Taya, Y ;
Jacks, T ;
Lees, JA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (03) :1002-1007
[9]
THE RETINOBLASTOMA PROTEIN IS PHOSPHORYLATED DURING SPECIFIC PHASES OF THE CELL-CYCLE [J].
BUCHKOVICH, K ;
DUFFY, LA ;
HARLOW, E .
CELL, 1989, 58 (06) :1097-1105
[10]
Cayirlioglu P, 2001, DEVELOPMENT, V128, P5085
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