Lymphangiogenesis and cancer metastasis

被引：644

作者：

Stacker, SA

Achen, MG

Jussila, L

Baldwin, ME

Alitalo, K ^{[1
]}

机构：

[1] Univ Helsinki, Haartman Inst, Mol Canc Biol Lab, FIN-00014 Helsinki, Finland

[2] Univ Helsinki, Haartman Inst, Ludwig Inst Canc Res, FIN-00014 Helsinki, Finland

[3] Univ Helsinki, Biomedicum, Ludwig Inst Canc Res, FIN-00014 Helsinki, Finland

[4] Univ Helsinki, Biomedicum, Mol Canc Biol Lab, FIN-00014 Helsinki, Finland

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 08期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nrc863

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lymphatic vessels are important for the spread of solid tumours, but the mechanisms that underlie lymphatic spread and the role of lymphangiogenesis (the growth of lymphatics) in tumour metastasis has been less clear This article reviews recent experimental and clinico-pathological data indicating that growth factors that stimulate lymphangiogenesis in tumours are associated with an enhanced metastatic process.

引用

页码：573 / 583

页数：11

共 124 条

[31]

Fong TAT, 1999, CANCER RES, V59, P99

[32]

GALE NW, IN PRESS DEV CELL

[33]

GALLAND F, 1993, ONCOGENE, V8, P1233

[34]

Geng L, 2001, CANCER RES, V61, P2413

[35] VEGF-A, VEGF-C, and VEGF-D in colorectal cancer progression [J].

George, ML ;

Tutton, MG ;

Janssen, F ;

Arnaout, A ;

Abulafi, AM ;

Eccles, SA ;

Swift, RI .

NEOPLASIA, 2001, 3 (05) :420-427

[36]

Gerber HP, 1999, DEVELOPMENT, V126, P1149

[37] Cancer statistics, 2001 [J].

Greenlee, RT ;

Hill-Harmon, MB ;

Murray, T ;

Thun, M .

CA-A CANCER JOURNAL FOR CLINICIANS, 2001, 51 (01) :15-36

[38]

HARVEY W, 1628, MOTION HEART BLOOD A

[39] Vascular endothelial growth factor-C expression and its relationship to pelvic lymph node status in invasive cervical cancer [J].

Hashimoto, I ;

Kodama, J ;

Seki, N ;

Hongo, A ;

Yoshinouchi, M ;

Okuda, H ;

Kudo, T .

BRITISH JOURNAL OF CANCER, 2001, 85 (01) :93-97

[40] Openings between defective endothelial cells explain tumor vessel leakiness [J].

Hashizume, H ;

Baluk, P ;

Morikawa, S ;

McLean, JW ;

Thurston, G ;

Roberge, S ;

Jain, RK ;

McDonald, DM .

AMERICAN JOURNAL OF PATHOLOGY, 2000, 156 (04) :1363-1380

← 1 2 3 4 5 6 7 8 9 10 →