Exploitation of the Ugi 4CC reaction: Preparation of small molecule combinatorial libraries via solid phase

被引：59

作者：

Short, KM ^{[1
]}

Ching, BW ^{[1
]}

Mjalli, AMM ^{[1
]}

机构：

[1] ONTOGEN CORP,CARLSBAD,CA 92009

来源：

TETRAHEDRON | 1997年 / 53卷 / 19期

关键词：

D O I：

10.1016/S0040-4020(97)00223-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The potential of the Ugi 4CC reaction has been explored with regard to the preparation of large combinatorial libraries of small organic molecules of varying structures. These include small-ring lactams, alpha-(dialkylamino)amides, hydantoin 4-imides, 2-thiohydantoin 4-imides and 5-(1'-aminoalkyl)tetraoles. (C) 1997 Published by Elsevier Science Ltd.

引用

页码：6653 / 6679

页数：27

共 28 条

[1]

Barany G., 1979, PEPTIDES, V2

[2]

Cao XD, 1995, BIOORG MED CHEM LETT, V5, P2953

[3]

CARGILL JF, 1996, INT S LAB AUT ROB P, P221

[4] DIVERSOMERS - AN APPROACH TO NONPEPTIDE, NONOLIGOMERIC CHEMICAL DIVERSITY [J].