Folic acid protects against potato glycoalkaloid alpha-chaconine-induced disruption of frog embryo cell membranes and developmental toxicity

被引：20

作者：

Friedman, M ^{[1
]}

Burns, CF ^{[1
]}

Butchko, CA ^{[1
]}

Blankemeyer, JT ^{[1
]}

机构：

[1] OKLAHOMA STATE UNIV, DEPT MICROBIOL & MOL GENET, STILLWATER, OK 74078 USA

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 1997年 / 45卷 / 10期

关键词：

alpha-chaconine; folic acid; food safety; frog embryos; glycoalkaloids; membrane potential; potatoes; teratogenicity;

D O I：

10.1021/jf9702205

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

To demonstrate whether folic acid can protect Xenopus embryos against reported adverse effects of the potato glycoalkaloid alpha-chaconine, the frog embryos were exposed simultaneously to the glycoalkaloid, folic acid (pteroylglutamic acid), and an electrochromic fluorescent dye, Di-4-ANEPPS, in a specially designed instrument that measures embryonic membrane potential. Folic acid decreased the chaconine-induced fluorescence, with a maximum decrease occurring at about 10 mg/L of both folic acid and the glycoalkaloid dissolved in solution. The protective effect was also operative in the frog embryo teratogenesis assay-Xenopus (FETAX), in which survival and teratogenicity of the whole embryos were the endpoints. Possible mechanisms of the protective effect and the possible significance of the results to food safety and health are discussed.

引用

页码：3991 / 3994

页数：4

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