MicroRNAs: Novel regulators in the hallmarks of human cancer

被引：383

作者：

Ruan, Kai ^{[1
]}

Fang, Xiaoguang ^{[1
]}

Ouyang, Gaoliang ^{[1
]}

机构：

[1] Xiamen Univ, Sch Life Sci, Key Lab, Minist Educ Cell Biol & Tumor Cell Engn, Xiamen 361005, Peoples R China

来源：

CANCER LETTERS | 2009年 / 285卷 / 02期

关键词：

miRNAs; Cancer; Oncogene; Tumor-suppressor gene; Hallmark; CELL-PROLIFERATION PATHWAYS; TUMOR-SUPPRESSOR GENE; GROWTH-FACTOR-BETA; MIR-200; FAMILY; BREAST-CANCER; COLON-CANCER; MESENCHYMAL TRANSITION; SEQUENCE VARIATIONS; REPRESSORS ZEB1; IN-VIVO;

D O I：

10.1016/j.canlet.2009.04.031

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs (miRNAs) are small non-coding RNAs of 18-25 nucleotides in length that function as negative regulators. miRNAs post-transcriptionally regulate gene expression by either inhibiting mRNA translation or inducing mRNA degradation, and participate in a wide variety of physiological and pathological cellular processes. Recent reports have revealed that the deregulation of miRNAs correlates with various human cancers and is involved in the initiation and progression of human cancers. miRNAs can act as oncogenes or tumor suppressors to inhibit the expression of cancer-related target genes and to promote or suppress tumorigenesis in various tissues. Therefore, abnormal miRNA expression can be regarded as a common feature of human cancers, and the identification of miRNAs and their respective targets may provide potential diagnostic and prognostic tumor biomarkers and new therapeutic strategies to treat cancers. In the present review, we discuss the emerging roles of miRNAs in the hallmarks of human cancers. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

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页码：116 / 126

页数：11

相关论文

共 143 条

[71] Regulation of the p27Kip1 tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation [J].

le Sage, Carlos ;

Nagel, Remco ;

Egan, David A. ;

Schrier, Mariette ;

Mesman, Elly ;

Mangiola, Annunziato ;

Anile, Corrado ;

Maira, Giulio ;

Mercatelli, Neri ;

Ciafre, Silvia Anna ;

Farace, Maria Giulia ;

Agami, Reuven .

EMBO JOURNAL, 2007, 26 (15) :3699-3708

[72] MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression [J].

Lee, Daniel Y. ;

Deng, Zhaoqun ;

Wang, Chia-Hui ;

Yang, Burton B. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (51) :20350-20355

[73] THE C-ELEGANS HETEROCHRONIC GENE LIN-4 ENCODES SMALL RNAS WITH ANTISENSE COMPLEMENTARITY TO LIN-14 [J].

LEE, RC ;

FEINBAUM, RL ;

AMBROS, V .

CELL, 1993, 75 (05) :843-854

[74] The tumor suppressor microRNA let-7 represses the HMGA2 oncogene [J].

Lee, Yong Sun ;

Dutta, Anindya .

GENES & DEVELOPMENT, 2007, 21 (09) :1025-1030

[75] MicroRNAs in Cancer [J].

Lee, Yong Sun ;

Dutta, Anindya .

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE, 2009, 4 :199-227

[76] miR-181a is an intrinsic modulator of T cell sensitivity and selection [J].

Li, Qi-Jing ;

Chau, Jacqueline ;

Ebert, Peter J. R. ;

Sylvester, Giselle ;

Min, Hyeyoung ;

Liu, Gwen ;

Braich, Ravi ;

Manoharan, Muthiah ;

Soutschek, Juergen ;

Skare, Petra ;

Klein, Lawrence O. ;

Davis, Mark M. ;

Chen, Chang-Zheng .

CELL, 2007, 129 (01) :147-161

[77] Loss of mir-146a function in hormone-refractory prostate cancer [J].

Lin, Shi-Lung ;

Chiang, Angela ;

Chang, Donald ;

Ying, Shao-Yao .

RNA, 2008, 14 (03) :417-424

[78] microRNAs and the immune response [J].

Tsitsiou, Eleni ;

Lindsay, Mark A. .

CURRENT OPINION IN PHARMACOLOGY, 2009, 9 (04) :514-520

[79] Interleukin-6-dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer [J].

Loeffler, Dennis ;

Brocke-Heidrich, Katja ;

Pfeifer, Gabriele ;

Stocsits, Claudia ;

Hackermueller, Joerg ;

Kretzschmar, Antje K. ;

Burger, Renate ;

Gramatzki, Martin ;

Blumert, Conny ;

Bauer, Kay ;

Cvijic, Helena ;

Ullmann, A. Kerstin ;

Stadler, Peter F. ;

Horn, Friedemann .

BLOOD, 2007, 110 (04) :1330-1333

[80] MicroRNA expression profiles classify human cancers [J].

Lu, J ;

Getz, G ;

Miska, EA ;

Alvarez-Saavedra, E ;

Lamb, J ;

Peck, D ;

Sweet-Cordero, A ;

Ebet, BL ;

Mak, RH ;

Ferrando, AA ;

Downing, JR ;

Jacks, T ;

Horvitz, HR ;

Golub, TR .

NATURE, 2005, 435 (7043) :834-838

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