Synthesis and cytotoxic activity of 17-carboxylic acid modified 23-hydroxy betulinic acid ester derivatives

被引：36

作者：

Bi, Yi

Xu, Jinyi

Wu, Xiaoming ^{[1
]}

Ye, Wencai

Yuan, Shengtao

Zhang, Luyong

机构：

[1] China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Peoples R China

[2] China Pharmaceut Univ, Dept Phytochem, Nanjing 210009, Peoples R China

[3] China Pharmaceut Univ, Natl Drug Screening Ctr, Nanjing 210009, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 05期

关键词：

23-hydroxy betulinic acid; 17-carboxylic acid modified ester derivatives; anti-tumor activity;

D O I：

10.1016/j.bmcl.2006.09.096

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

New 17-carboxylic acid modified 23-hydroxy betulinic acid ester derivatives were prepared and tested for cytotoxic activity on five cancer cell lines in vitro: all tested compounds showed stronger cytotoxic activity than 23-hydroxy betulinic acid and betulinic acid. In addition, compound 5a was tested for anti-tumor activity in vivo: it had much better anti-tumor activity than 23-OH betulinic acid and had similar anti-tumor activity with cyclophosphamide and 5-fluorouracil. (c) 2006 Elsevier Ltd. All rights reserved.

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收藏

页码：1475 / 1478

页数：4

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