Ribozyme mechanism revisited: Evidence against direct coordination of a Mg2+ ion with the pro-R oxygen of the scissile phosphate in the transition state of a hammerhead ribozyme-catalyzed reaction

被引:59
作者
Zhou, DM
Kumar, PKR
Zhang, LH
Taira, K
机构
[1] UNIV TSUKUBA, INST APPL BIOCHEM, TSUKUBA, IBARAKI 305, JAPAN
[2] MINIST INT TRADE & IND, AGCY IND SCI & TECHNOL, NATL INST BIOSCI & HUMAN TECHNOL, TSUKUBA, IBARAKI 305, JAPAN
[3] BEIJING MED UNIV, BEIJING 100083, PEOPLES R CHINA
关键词
D O I
10.1021/ja961756u
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:8969 / 8970
页数:2
相关论文
共 29 条
[1]  
Benkovic S. J., 1973, ENZYMES, P201
[2]   EVIDENCE FOR THE ROLE OF SOLVATED METAL HYDROXIDE IN THE HAMMERHEAD CLEAVAGE MECHANISM [J].
DAHM, SC ;
DERRICK, WB ;
UHLENBECK, OC .
BIOCHEMISTRY, 1993, 32 (48) :13040-13045
[3]   ROLE OF DIVALENT METAL-IONS IN THE HAMMERHEAD RNA CLEAVAGE REACTION [J].
DAHM, SC ;
UHLENBECK, OC .
BIOCHEMISTRY, 1991, 30 (39) :9464-9469
[5]   NUCLEOSIDE PHOSPHOROTHIOATES [J].
ECKSTEIN, F .
ANNUAL REVIEW OF BIOCHEMISTRY, 1985, 54 :367-402
[6]  
FREY PA, 1989, ADV ENZYMOL RAMB, V62, P119
[7]   BOND ORDER AND CHARGE LOCALIZATION IN NUCLEOSIDE PHOSPHOROTHIOATES [J].
FREY, PA ;
SAMMONS, RD .
SCIENCE, 1985, 228 (4699) :541-545
[8]  
FREY PA, 1982, NEW COMPREHENSIVE BI, V3, P201
[9]   SIMPLE RNA ENZYMES WITH NEW AND HIGHLY SPECIFIC ENDORIBONUCLEASE ACTIVITIES [J].
HASELOFF, J ;
GERLACH, WL .
NATURE, 1988, 334 (6183) :585-591
[10]   RIBOZYME-CATALYZED AND NONENZYMATIC REACTIONS OF PHOSPHATE DIESTERS - RATE EFFECTS UPON SUBSTITUTION OF SULFUR FOR A NONBRIDGING PHOSPHORYL OXYGEN ATOM [J].
HERSCHLAG, D ;
PICCIRILLI, JA ;
CECH, TR .
BIOCHEMISTRY, 1991, 30 (20) :4844-4854