Serum Leptin Levels in Patients Undergoing Carotid Endarterectomy: A Pilot Study

被引：13

作者：

Bountouris, Ioannis

Paraskevas, Kosmas I. ^{[1
]}

Koutouzis, Michael ^{[2
]}

Tzavara, Vassiliki

Nikolaou, Nikolaos

Nomikos, Alexandros

Barbatis, Calypso

Andrikopoulos, Vassilios

Mikhailidis, Dimitri P. ^{[3
]}

Andrikopoulou, Maria

Kyriakides, Zenon S.

Georgopoulos, Sotirios ^{[4
]}

Michail, Panagiotis O. ^{[4
]}

Bastounis, Elias ^{[4
]}

机构：

[1] Red Cross Hosp, Dept Vasc Surg, Athens, Greece

[2] Sahlgrens Univ Hosp, Gothenburg, Sweden

[3] UCL, Sch Med, Dept Clin Biochem, Vasc Dis Prevent Clin, London W1N 8AA, England

[4] Univ Athens, Sch Med, Laikon Hosp, Dept Surg 1, GR-11527 Athens, Greece

来源：

ANGIOLOGY | 2009年 / 60卷 / 06期

关键词：

leptin; carotid artery disease; inflammation; cardiovascular events; INTIMA-MEDIA THICKNESS; PLASMA LEPTIN; ATHEROSCLEROTIC PLAQUES; ARTERY-DISEASE; HEART-DISEASE; STATINS; INFLAMMATION; RISK; DESTABILIZATION; STABILIZATION;

D O I：

10.1177/0003319709350133

中图分类号：

R6 [外科学];

学科分类号：

100210 [外科学];

摘要：

Introduction: Elevated serum leptin levels are associated with cardiovascular events. We investigated the role of serum leptin in patients undergoing carotid endarterectomy (CEA). Methods: A total of 74 patients (55 men; 38 symptomatic and 36 asymptomatic; mean age 66.9 +/- 8.2 years) undergoing CEA for >70% carotid artery stenosis were enrolled. Results: Serum leptin levels were lower in symptomatic compared with asymptomatic patients (7.1 +/- 1.3 vs 14.4 +/- 4.7 ng/dL; P < .001). Interleukin-6 (IL-6) levels were higher in symptomatic compared with asymptomatic patients (4.3 +/- 1.7 vs 3.3 +/- 1.1 pg/dL; P = .017). Symptomatic patients had more intense macrophage accumulation (0.7% +/- 0.1% vs 0.3% +/- 0.1%; P < .001). Serum leptin and serum IL-6 levels were independently associated with the presence of symptoms in multivariate analysis. Conclusion: Serum leptin levels were decreased in symptomatic carotid artery disease. This finding requires further investigation in larger studies.

引用

页码：698 / 704

页数：7

共 33 条

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