Ontogenetic expression of chromogranin A and its derived peptides, WE-14 and pancreastatin, in the rat neuroendocrine system

被引：17

作者：

Barkatullah, SC ^{[1
]}

Curry, WJ ^{[1
]}

Johnston, CF ^{[1
]}

Hutton, JC ^{[1
]}

Buchanan, KD ^{[1
]}

机构：

[1] QUEENS UNIV BELFAST,DEPT MED,SCH CLIN MED,BELFAST BT12 6BJ,ANTRIM,NORTH IRELAND

来源：

HISTOCHEMISTRY AND CELL BIOLOGY | 1997年 / 107卷 / 03期

关键词：

D O I：

10.1007/s004180050110

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The ontogenetic expression of chromogranin A (CgA) and its derived peptides, WE-14 and pancreastatin (PST), was studied in the rat neuroendocrine system employing immunohistochemical analysis of fetal and neonatal specimens from 12.5-day embryos (E12.5), to 42-day postnatal (P42) rats. C(g)A immunostaining was first detected in endocrine cells of the pancreas, stomach, intestine, adrenal gland and thyroid at E13.5, E14.5, E15.5, E15.5 and E18.5, respectively. PST-like immunoreactivity was detected in endocrine cells of the pancreas at E13.5, stomach, intestine at E15.5, adrenal gland at E17.5 and thyroid at E18.5. WE-14 immunoreactivity was first observed in the immature pancreas at E15.5, mucosal cells of the stomach at E15.5, scattered chromaffin cells in the immature adrenal gland and mucosal cells of the intestine at E17.5 and thyroid parafollicular cells at E18.5. These data confirm that the translation of the CgA gene is regulated differentially in various neuroendocrine tissues and, moreover, suggests that the posttranslational processing of the molecule is developmentally controlled.

引用

页码：251 / 257

页数：7

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