In vitro investigation of the susceptibility of Acintetobacter baumannii strains isolated from clinical specimens to ampicillin/sulbactam alone and in combination with amikacin

被引：27

作者：

Savov, E ^{[1
]}

Chankova, D

Vatcheva, R

Dinev, N

机构：

[1] Mil Med Acad, Sofia, Bulgaria

[2] NCIPD, Sofia, Bulgaria

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2002年 / 20卷 / 05期

关键词：

Acinetobacter baumannii; antimicrobial; partial synergistic effect;

D O I：

10.1016/S0924-8579(02)00207-8

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The sensitivity of 52 strains of Acinetobacter baumannii was determined to 13 antimicrobial drugs. All strains tested were multiresistant. Compared with MICs of amikacin and ampicillin/sulbactam alone, there was a significant decrease in MICs for both drugs when the combination was used. The results of the in vitro study of this combination showed a synergistic or partial synergistic effect in 98% of the strains. (C) 2002 Published by Elsevier Science B.V. and International Society of Chemotherapy.

引用

页码：390 / 392

页数：3

共 15 条

[1] In-vitro activity of cephalosporins alone and combined with sulbactam against various strains of Acinetobacter baumannii with different antibiotic resistance profiles [J].

Aubert, G ;

Guichard, D ;

Vedel, G .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1996, 37 (01) :155-160

[2]

BEERENBAUM MA, 1978, J INFECT DIS, V137, P122

[3]

GRASER Y, 1993, J CLIN MICROBIOL, V31, P2417

[4]

HARSTEIN A, 1988, AM J MED, V8, P624

[5]

KAWAHATA Y, 1983, P 13 INT C CHEM VIEN

[6] ANTIMICROBIAL SUSCEPTIBILITIES OF CLINICAL ISOLATES OF ACINETOBACTER-BAUMANNII FROM SINGAPORE [J].

KUAH, BG ;

KUMARASINGHE, G ;

DORAN, J ;

CHANG, HR .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (10) :2502-2503

[7]

LABIA R, 1986, REV INFECT DIS S5, V8, P496

[8]

*NAT COMM CLIN LAB, 1995, M100S6M2A5 NCCLS, V15

[9]

*NAT COMM CLIN LAB, 1990, M2A2 NCCLS

[10]

Savov E, 1981, V MED DELO, V5, P39

← 1 2 →