Influenza neuraminidase inhibitors as antiviral agents

被引:7
作者
Babu, Y. Sudhakara [1 ]
Chand, Pooran [1 ]
Kotian, Pravin L. [1 ]
机构
[1] BioCryst Pharmaceut Inc, Birmingham, AL 35244 USA
来源
ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 41 | 2006年 / 41卷
关键词
D O I
10.1016/S0065-7743(06)41019-8
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:287 / 297
页数:11
相关论文
共 78 条
[1]   Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-Guanidino-Neu5Ac2en (Zanamivir) modified in the glycerol side-chain [J].
Andrews, DM ;
Cherry, PC ;
Humber, DC ;
Jones, PS ;
Keeling, SP ;
Martin, PF ;
Shaw, CD ;
Swanson, S .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1999, 34 (7-8) :563-574
[2]  
[Anonymous], 2006, WHO REP
[3]  
Arruda E, 1996, ADV EXP MED BIOL, V394, P175
[4]   Hydrophobic benzoic acids as inhibitors of influenza neuraminidase [J].
Atigadda, VR ;
Brouillette, WJ ;
Duarte, F ;
Babu, YS ;
Bantia, S ;
Chand, P ;
Chu, NM ;
Montgomery, JA ;
Walsh, DA ;
Sudbeck, E ;
Finley, J ;
Air, GM ;
Luo, M ;
Laver, GW .
BIOORGANIC & MEDICINAL CHEMISTRY, 1999, 7 (11) :2487-2497
[5]   Potent inhibition of influenza sialidase by a benzoic acid containing a 2-pyrrolidinone substituent [J].
Atigadda, VR ;
Brouillette, WJ ;
Duarte, F ;
Ali, SM ;
Babu, YS ;
Bantia, S ;
Chand, P ;
Chu, N ;
Montgomery, JA ;
Walsh, DA ;
Sudbeck, EA ;
Finley, J ;
Luo, M ;
Air, GM ;
Laver, GW .
JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (13) :2332-2343
[6]   BCX-1812 (RWJ-270201): Discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design [J].
Babu, YS ;
Chand, P ;
Bantia, S ;
Kotian, P ;
Dehghani, A ;
El-Kattan, Y ;
Lin, TH ;
Hutchison, TL ;
Elliott, AJ ;
Parker, CD ;
Ananth, SL ;
Horn, LL ;
Laver, GW ;
Montgomery, JA .
JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (19) :3482-3486
[7]   Synthesis of an influenza neuraminidase inhibitor intermediate via a highly diastereoselective coupling reaction [J].
Barnes, DM ;
McLaughlin, MA ;
Oie, T ;
Rasmussen, MW ;
Stewart, KD ;
Wittenberger, SJ .
ORGANIC LETTERS, 2002, 4 (09) :1427-1430
[8]   Aromatic sialic acid analogues as potential inhibitors of influenza virus neuraminidase [J].
Bianco, A ;
Brufani, M ;
Melchioni, C .
FARMACO, 2001, 56 (04) :305-309
[9]   Pyrroliidinobenzoic acid inhibitors of influenza virus neuraminidase: Modifications of essential pyrrolidinone ring substituents [J].
Brouillette, WJ ;
Bajpai, SN ;
Ali, SM ;
Velu, SE ;
Atigadda, VR ;
Lommer, BS ;
Finley, JB ;
Luo, M ;
Air, GM .
BIOORGANIC & MEDICINAL CHEMISTRY, 2003, 11 (13) :2739-2749
[10]   Design of benzoic acid inhibitors of influenza neuraminidase containing a cyclic substitution for the N-acetyl grouping [J].
Brouillette, WJ ;
Atigadda, VR ;
Luo, M ;
Air, GM ;
Babu, YS ;
Bantia, S .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (14) :1901-1906