Negative regulators of toll-like receptor 4-mediated macrophage inflammatory response

被引：28

作者：

Butchar, Jonathan P.

Parsa, Kishore V. L.

Marsh, Clay B.

Tridandapani, Susheela

机构：

[1] Ohio State Univ, Dorothy M Davis Heart & Lung Res Inst, Dept Internal Med, Columbus, OH 43210 USA

[2] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

来源：

CURRENT PHARMACEUTICAL DESIGN | 2006年 / 12卷 / 32期

关键词：

TLR4; inflammation; regulation; lipopolysaccharide; signal transduction; SHIP; PTEN;

D O I：

10.2174/138161206778743574

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Activation of macrophages through TLR4, the receptor for the bacterial endotoxin LPS, results in a potent inflammatory response aimed at eliminating the invading pathogen. Excessive production of inflammatory mediators is harmful to host tissue and in extreme cases can result in fatal outcomes. This inflammatory response is, therefore, tightly regulated by negative regulatory mechanisms that act to maintain homeostasis. This review will summarize recent advances in our current understanding of molecular mechanisms that regulate macrophage TLR4 signaling.

引用

收藏

页码：4143 / 4153

页数：11

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