A new approach to the synthesis of oligonucleotides and their phosphorothioate analogues in solution

被引：23

作者：

Reese, CB

Song, QL

机构：

[1] Department of Chemistry, King's College London, Strand

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(97)10073-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new approach to the synthesis of oligonucleotides and oligonucleotide phosphorothioates in solution is described; it is based on H-phosphonate coupling at 40 degrees C, followed by in situ sulfur-transfer with either N-[(4chlorophenyl)sulfanyl]phthalimide 19 or 4-[(2-cyanoethyl)sulfanyl]morpholine-3,5-dione 21. (C) 1997 Elsevier Science Ltd.

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页码：2787 / 2792

页数：6

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