Senescence signature in skin biopsies from systemic sclerosis patients treated with senolytic therapy: potential predictor of clinical response?

被引：40

作者：

Martyanov, Viktor ^{[1
]}

Whitfield, Michael L. ^{[1
]}

Varga, John ^{[2
]}

机构：

[1] Geisel Sch Med Dartmouth, Hanover, NH 03755 USA

[2] Northwestern Univ, Chicago, IL 60611 USA

来源：

ARTHRITIS & RHEUMATOLOGY | 2019年 / 71卷 / 10期

关键词：

D O I：

10.1002/art.40934

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

引用

收藏

页码：1766 / 1767

页数：2

相关论文

共 8 条

[1]

CLEMENTS P, 1995, J RHEUMATOL, V22, P1281

[2]

The Reactome Pathway Knowledgebase [J].

Fabregat, Antonio ;

Jupe, Steven ;

Matthews, Lisa ;

Sidiropoulos, Konstantinos ;

Gillespie, Marc ;

Garapati, Phani ;

Haw, Robin ;

Jassal, Bijay ;

Korninger, Florian ;

May, Bruce ;

Milacic, Marija ;

Roca, Corina Duenas ;

Rothfels, Karen ;

Sevilla, Cristoffer ;

Shamovsky, Veronica ;

Shorser, Solomon ;

Varusai, Thawfeek ;

Viteri, Guilherme ;

Weiser, Joel ;

Wu, Guanming ;

Stein, Lincoln ;

Hermjakob, Henning ;

D'Eustachio, Peter .

NUCLEIC ACIDS RESEARCH, 2018, 46 (D1) :D649-D655

[3]

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study [J].

Justice, Jamie N. ;

Nambiar, Anoop M. ;

Tchkonia, Tamar ;

LeBrasseur, Nathan K. ;

Pascual, Rodolfo ;

Hashmi, Shahrukh K. ;

Prata, Larissa ;

Masternak, Michal M. ;

Kritchevsky, Stephen B. ;

Musi, Nicolas ;

Kirkland, James L. .

EBIOMEDICINE, 2019, 40 :554-563

[4]

The Molecular Signatures Database Hallmark Gene Set Collection [J].

Liberzon, Arthur ;

Birger, Chet ;

Thorvaldsdottir, Helga ;

Ghandi, Mahmoud ;

Mesirov, Jill P. ;

Tamayo, Pablo .

CELL SYSTEMS, 2015, 1 (06) :417-425

[5]

Novel lung imaging biomarkers and skin gene expression subsetting in dasatinib treatment of systemic sclerosis-associated interstitial lung disease [J].

Martyanov, Viktor ;

Kim, Grace-Hyun J. ;

Hayes, Wendy ;

Dui, Shuyan ;

Ganguly, Bishu J. ;

Sy, Oumar ;

Lee, Sun Ku ;

Bogatkevich, Galina S. ;

Schieven, Gary L. ;

Schiopu, Elena ;

Marangoni, Roberta Goncalves ;

Goldin, Jonathan ;

Whitfield, Michael L. ;

Varga, John .

PLOS ONE, 2017, 12 (11)

[6]

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes [J].

Mootha, VK ;

Lindgren, CM ;

Eriksson, KF ;

Subramanian, A ;

Sihag, S ;

Lehar, J ;

Puigserver, P ;

Carlsson, E ;

Ridderstråle, M ;

Laurila, E ;

Houstis, N ;

Daly, MJ ;

Patterson, N ;

Mesirov, JP ;

Golub, TR ;

Tamayo, P ;

Spiegelman, B ;

Lander, ES ;

Hirschhorn, JN ;

Altshuler, D ;

Groop, LC .

NATURE GENETICS, 2003, 34 (03) :267-273

[7]

Cellular senescence mediates fibrotic pulmonary disease [J].

Schafer, Marissa J. ;

White, Thomas A. ;

Iijima, Koji ;

Haak, Andrew J. ;

Ligresti, Giovanni ;

Atkinson, Elizabeth J. ;

Oberg, Ann L. ;

Birch, Jodie ;

Salmonowicz, Hanna ;

Zhu, Yi ;

Mazula, Daniel L. ;

Brooks, Robert W. ;

Fuhrmann-Stroissnigg, Heike ;

Pirtskhalava, Tamar ;

Prakash, Y. S. ;

Tchkonia, Tamara ;

Robbins, Paul D. ;

Aubry, Marie Christine ;

Passos, Joao F. ;

Kirkland, James L. ;

Tschumperlin, Daniel J. ;

Kita, Hirohito ;

LeBrasseur, Nathan K. .

NATURE COMMUNICATIONS, 2017, 8

[8]

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles [J].

Subramanian, A ;

Tamayo, P ;

Mootha, VK ;

Mukherjee, S ;

Ebert, BL ;

Gillette, MA ;

Paulovich, A ;

Pomeroy, SL ;

Golub, TR ;

Lander, ES ;

Mesirov, JP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (43) :15545-15550