Cytotoxic Xanthone Constituents of the Stem Bark of Garcinia mangostana (Mangosteen)

被引：86

作者：

Han, Ah-Reum ^{[1
]}

Kim, Jeong-Ah ^{[1
]}

Lantvit, Daniel D. ^{[2
]}

Leonardus, B. S. Kardono ^{[3
]}

Riswan, Soedarsono ^{[4
]}

Chai, Heebyung ^{[1
]}

de Blanco, Esperanza J. Carcache ^{[1
]}

Farnsworth, Norman R. ^{[2
]}

Swanson, Steven M. ^{[2
]}

Kinghorn, A. Douglas ^{[1
]}

机构：

[1] Ohio State Univ, Coll Pharm, Columbus, OH 43210 USA

[2] Univ Illinois, Coll Pharm, Chicago, IL 60612 USA

[3] Indonesian Inst Sci, Res Ctr Chem, Tangerang 15310, Indonesia

[4] Indonesian Inst Sci, Biol Res Ctr, Herbarium Bogoriense, Bogor 16122, Indonesia

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 11期

关键词：

PRENYLATED XANTHONES;

D O I：

10.1021/np900517h

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided fractionation of a chloroform-soluble extract of Garcinia mangostana stem bark, using the HT-29 human colon cancer cell line and an enzyme-based ELISA NF-kappa B assay, led to the isolation of a new xanthone, 11-hydroxy-3-O-methyl-1-isomangostin (1). The structure of 1 was elucidated by spectroscopic data analysis. In addition, 10 other known compounds, 11-hydroxy-1-isomangostin (2), 11 alpha-mangostanin (3), 3-isomangostin (4), alpha-mangostin (5), beta-mangostin (6), garcinone D (7), 9-hydroxycalabaxanthone (8), 8-deoxygartanin (9), gartanin (10), and cratoxyxanthone (11), were isolated. Compounds 4-8 exhibited cytotoxicity against the HT-29 cell line with ED50 values of 4.9, 1.7, 1.7, 2.3, and 9.1 mu M, respectively. In an ELISA NF-kappa B assay, compounds 5-7, 9, and 10 inhibited p65 activation with IC50 values of 15.9, 12.1, 3.2 11.3, and 19.0 mu M, respectively, and 6 showed p50 inhibitory activity with an IC50 value of 7.5 mu M. alpha-Mangostin (5) was further tested in an in vivo hollow fiber assay, using HT-29, LNCaP, and MCF-7 cells, but it was found to be inactive at the highest dose tested (20 mg/kg).

引用

页码：2028 / 2031

页数：4

共 31 条

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