TGF-β and IL-17 serum levels and specific immunotherapy

被引：26

作者：

Ciprandi, Giorgio ^{[1
]}

De Amici, Mara ^{[2
]}

Negrini, Simone ^{[1
]}

Marseglia, Gianluigi ^{[2
]}

Tosca, Maria Angela ^{[3
]}

机构：

[1] Univ Genoa, Dept Internal Med, Aziendo Osped Univ San Martino, I-16126 Genoa, Italy

[2] Univ Pavia, Dept Pediat Sci, Pediat Clin, Fdn IRCCS San Matteo, I-27100 Pavia, Italy

[3] Ist Giannina Gaslini, I-16148 Genoa, Italy

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2009年 / 9卷 / 10期

关键词：

TGF-beta; IL-17; Allergic rhinitis; Sublingual immunotherapy; INTERFERON-GAMMA-PRODUCTION; SUBLINGUAL IMMUNOTHERAPY; ALLERGIC RHINITIS; INTERLEUKIN-17; UPDATE; ASTHMA; INFLAMMATION; IMMUNOLOGY; MECHANISMS; IMPACT;

D O I：

10.1016/j.intimp.2009.07.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Two new T cell subsets may be involved in allergic rhinitis (AR) pathogenesis: Th17 and T regulatory cells, mainly producing IL-17 and TGF-beta respectively. Successful Sublingual Immunotherapy (SLIT) induces relevant immunological changes, thus the aim of this study was to evaluate serum IL-17 and TGF-beta levels in AR patients treated with SLIT for 2 years. Patients' blood samples were collected before initiating SLIT (baseline), three months after the end of the first pre-seasonal SLIT course, and at the end of the second pre-seasonal course. IL-17 was detectable only in the most severe allergic patients. SLIT significantly induced an increase in serum TGF-beta levels. There was moreover a significant relationship between TGF-beta and symptom severity and drug use at the end of the study. Therefore, this study provides clinically relevant evidence that two pre-seasonal SLIT courses may significantly affect serum TGF-beta levels. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：1247 / 1249

页数：3

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