Antidepressant drugs and cytokines in mood disorders

被引：18

作者：

Nishida, A

Hisaoka, K

Zensho, H

Uchitomi, Y

Morinobu, S

Yamawaki, S

机构：

[1] Natl Kure Med Ctr, Inst Clin Res, Dept Psychiat & Neurosci, Kure 7370023, Japan

[2] Natl Canc Ctr, Res Inst E, Psychooncol Div, Kashiwa, Chiba 2778577, Japan

[3] Hiroshima Univ, Grad Sch Med, Dept Psychiat & Neurosci, Hiroshima 7348551, Japan

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2002年 / 2卷 / 12期

关键词：

mood disorder; bipolar disorder; depression; antidepressant; cytokine; interleukin; interferon; sickness behavior;

D O I：

10.1016/S1567-5769(02)00190-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This article reviews recent developments in cytokine research that pertain to pharmacological treatment of mood disorders such as antidepressants and lithium. We review the possible involvement of cytokines in mood disorders and their role in the therapeutic effects of antidepressant drugs. Growing evidence suggests that specific cytokines signal the brain to generate neurochemical, neuroimmune, neuroendocrine and behavior changes. An imbalance of cytokines within the central nervous system (CNS), or even systemically, may play a role in the pathophysiology of mood disorders. Modulation of these cytokines by chronic antidepressant treatment may result in restored balance. However, the effect of antidepressants on cytokines is still unclear both in clinical and preclinical research due to limited data. Further research is needed to clarify the involvement of cytokines in mood disorders. Understanding this relationship may lead to rational, therapeutic improvements in antidepressant and mood stabilizing drugs. (C) 2002 Published by Elsevier Science B.V.

引用

页码：1619 / 1626

页数：8

共 45 条

[1] Interleukin-1β production in dysthymia before and after pharmacotherapy
Anisman, H
Ravindran, AV
Griffiths, J
Merali, Z
[J]. BIOLOGICAL PSYCHIATRY, 1999, 46 (12) : 1649 - 1655
[2] Chronic treatment with the atypical antidepressant tianeptine attenuates sickness behavior induced by peripheral but not central lipopolysaccharide and interleukin-1β in the rat
Castanon, N
Bluthé, RM
Dantzer, R
[J]. PSYCHOPHARMACOLOGY, 2001, 154 (01) : 50 - 60
[3] Cytokines and depression: fortuitous or causative association?
Dantzer, R
Wollman, E
Vitkovic, L
Yirmiya, R
[J]. MOLECULAR PSYCHIATRY, 1999, 4 (04) : 328 - 332
[4] DANTZER R, 1999, ADV EXP MED BIOL, V461
[5] Neural plasticity to stress and antidepressant treatment
Duman, RS
Malberg, J
Thome, J
[J]. BIOLOGICAL PSYCHIATRY, 1999, 46 (09) : 1181 - 1191
[6] Dunn AJ, 1999, ADV EXP MED BIOL, V461, P117
[7] The reductions in sweetened milk intake induced by interleukin-1 and endotoxin are not prevented by chronic antidepressant treatment
Dunn, AJ
Swiergiel, AH
[J]. NEUROIMMUNOMODULATION, 2001, 9 (03) : 163 - 169
[8] SUCCESSFUL TREATMENT OF INTERFERON ALFA-INDUCED MOOD DISORDER WITH NORTRIPTYLINE
GOLDMAN, LS
[J]. PSYCHOSOMATICS, 1994, 35 (04) : 412 - 413
[9] Cytokines and sickness behavior: implications from knockout animal models
Inui, A
[J]. TRENDS IN IMMUNOLOGY, 2001, 22 (09) : 469 - 473
[10] Plasma concentrations of interleukin-1β, interleukin-6, soluble interleukin-2 receptor and tumor necrosis factor α of depressed patients in Japan
Kagaya, A
Kugaya, A
Takebayashi, M
Fukue-Saeki, M
Saeki, T
Yamawaki, S
Uchitomi, Y
[J]. NEUROPSYCHOBIOLOGY, 2001, 43 (02) : 59 - 62

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