An organic self-regulating microfluidic system

被引:64
作者
Eddington, DT [1 ]
Liu, RH
Moore, JS
Beebe, DJ
机构
[1] Univ Wisconsin, Dept Biomed Engn, Madison, WI 53706 USA
[2] Univ Illinois, Beckman Inst, Urbana, IL 61801 USA
关键词
D O I
10.1039/b108078d
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
In this paper we present an organic feedback scheme that merges microfluidics and responsive materials to address several limitations of current microfluidic systems. By using in situ fabrication and by taking advantage of microscale phenomena (e.g., laminar flow, short diffusion times), we have demonstrated feedback control of the output pH in a completely organic system. The system autonomously regulates an output stream at pH 7 under a range of input flow conditions. A single responsive hydrogel component performs the functionality of traditional feedback system components. Vertically stacked laminar flow is used to improve the time response of the hydrogel actuator. A star shaped orifice is utilized to improve the flow characteristics of the membrane/orifice valve. By changing the chemistry of the hydrogel component, the system can be altered to regulate flow based on hydrogels sensitive to temperature, light, biological/molecular, and others.
引用
收藏
页码:96 / 99
页数:4
相关论文
共 23 条
  • [1] Functional hydrogel structures for autonomous flow control inside microfluidic channels
    Beebe, DJ
    Moore, JS
    Bauer, JM
    Yu, Q
    Liu, RH
    Devadoss, C
    Jo, BH
    [J]. NATURE, 2000, 404 (6778) : 588 - +
  • [2] An Integrated Micromachined Electrochemical Pump and Dosing System
    Bohm, S.
    Olthuis, W.
    Bergveld, P.
    [J]. BIOMEDICAL MICRODEVICES, 1999, 1 (02) : 121 - 130
  • [3] Rapid prototyping of microfluidic systems in poly(dimethylsiloxane)
    Duffy, DC
    McDonald, JC
    Schueller, OJA
    Whitesides, GM
    [J]. ANALYTICAL CHEMISTRY, 1998, 70 (23) : 4974 - 4984
  • [4] GRAHAM NB, 1994, 2 EUR C SMART STRUCT, P31
  • [5] Doing immunology on a chip
    Hagmann, M
    [J]. SCIENCE, 2000, 290 (5489) : 82 - 83
  • [6] A rapid diffusion immunoassay in a T-sensor
    Hatch, A
    Kamholz, AE
    Hawkins, KR
    Munson, MS
    Schilling, EA
    Weigl, BH
    Yager, P
    [J]. NATURE BIOTECHNOLOGY, 2001, 19 (05) : 461 - 465
  • [7] Three-dimensional micro-channel fabrication in polydimethylsiloxane (PDMS) elastomer
    Jo, BH
    Van Lerberghe, LM
    Motsegood, KM
    Beebe, DJ
    [J]. JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, 2000, 9 (01) : 76 - 81
  • [8] Totally synthetic polymer gels responding to external glucose concentration: Their preparation and application to on-off regulation of insulin release
    Kataoka, K
    Miyazaki, H
    Bunya, M
    Okano, T
    Sakurai, Y
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (48) : 12694 - 12695
  • [9] A microfluidic pH-regulation system based on printed circuit board technology
    Läritz, C
    Pagel, L
    [J]. SENSORS AND ACTUATORS A-PHYSICAL, 2000, 84 (03) : 230 - 235
  • [10] LIU RH, 2001, IN PRESS J MICROELEC