Carbon monoxide disposition and permeability-surface area product in the foetal circulation of the perfused term human placenta

被引：14

作者：

Sangalli, MR

McLean, AJ

Peek, MJ

Rivory, LP

Le Couteur, DG

机构：

[1] Canberra Hosp, Ctr Perinatal Care, Canberra, ACT 2605, Australia

[2] Wellington Sch Med & Hlth Sci, Dept Obstet & Gynaecol, Wellington 6002, New Zealand

[3] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 0200, Australia

[4] Univ Sydney, Dept Pharmacol, Sydney, NSW 2006, Australia

[5] Concord RG Hosp, Ctr Educ & Res Ageing, Concord, ACT 2139, Australia

[6] Univ Sydney, Canberra Clin Sch, Sydney, NSW 2605, Australia

来源：

PLACENTA | 2003年 / 24卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1053/plac.2002.0877

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In order to estimate the placental barrier to gas transfer, a novel carbon monoxide (CO) wash-in method was used to estimate the permeability-surface area (PS) product for the transfer of gas across the foetal circulation in the perfused human term placenta. The PS product for CO was 0.0096 +/- 0.006 ml/s/g or 0.012 +/- 0.007 ml/s/g using compartmental or Crone-Renkin analysis, respectively. Using this result and a published estimate of the placental capillary surface area, the permeability coefficient to CO across the foetal circulation was found to be approximately 4 x 10(-5) cm/s. This result is compatible with the hypothesis that the foetal circulation of the human placenta imposes a potentially significant barrier to gas transfer. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：8 / 11

页数：4

共 19 条

[11] THEORETICAL ANALYSIS OF FACTORS AFFECTING PLACENTAL O2 TRANSFER [J].