Parallel Isotope-Based Quantification of Modified tRNA Nucleosides

被引：36

作者：

Brueckl, Tobias ^{[1
]}

Globisch, Daniel ^{[1
]}

Wagner, Mirko ^{[1
]}

Mueller, Markus ^{[1
]}

Carell, Thomas ^{[1
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Dept Chem & Biochem, Ctr Integrated Prot Sci CiPSM, D-81377 Munich, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 42期

关键词：

bioanalytical methods; gene translation; isotope labeling; modiomics; tRNA; LIQUID-CHROMATOGRAPHY; CANCER; MITOCHONDRIA; NUCLEOTIDE; EXPRESSION; QUEUOSINE; TRNA(LYS); MODOMICS; DATABASE; DNA;

D O I：

10.1002/anie.200902740

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Modifications make a difference: An isotope-based mass spectrometry method allows the facile and quantitative analysis of modified tRNA nucleosides in various types of cells. This method could be capable of distinguishing between individual cell lines as well as between healthy tissue and cancer cells. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7932 / 7934

页数：3

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