Amphotericin B lipid complex exerts additive antifungal activity in combination with polymorphonuclear leucocytes against Scedosporium prolificans and Scedosporium apiospermum

被引：41

作者：

Gil-Lamaignere, C

Roilides, E

Maloukou, A

Georgopoulou, I

Petrikkos, G

Walsh, TJ

机构：

[1] NCI, Immunocompromised Host Sect, Paediat Oncol Branch, Bethesda, MD 20892 USA

[2] Aristotle Univ, Hippokratio Hosp, Paediat Dept 3, GR-54642 Thessaloniki, Greece

[3] Univ Athens, Propedeut Dept Med 1, GR-11527 Athens, Greece

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2002年 / 50卷 / 06期

关键词：

amphotericin B formulations; Scedosporium; polymorphonuclear leucocytes;

D O I：

10.1093/jac/dkf198

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Scedosporium prolificans and Scedosporium apiospermum are resistant to most antifungal agents and cause refractory pulmonary and disseminated infections. The combined effects of deoxycholate amphotericin B, amphotericin B lipid complex and liposomal amphotericin B with human polymorphonuclear leucocytes (PMNs) in damaging hyphae of these fungi were evaluated by XTT assay. Amphotericin B lipid complex displayed a significant additive effect with PMNs against both Scedosporium species (22% for S. prolificans and 81% for S. apiospermum; P < 0.04). None of the formulations adversely affected the PMN antifungal activity. These findings may be important in designing better strategies for management of infections due to these organisms.

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收藏

页码：1027 / 1030

页数：4

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