Association of peroxisome proliferator-activated receptor delta+294T/C with body mass index and interaction with peroxisome proliferator-activated receptor alpha L162V

被引：38

作者：

Aberle, J. ^{[1
]}

Hopfer, I. ^{[1
]}

Beil, F. U. ^{[1
]}

Seedorf, U. ^{[1
]}

机构：

[1] Univ Hamburg, Klinikum Eppendorf, Zentrum Innere Med, D-20246 Hamburg, Germany

来源：

INTERNATIONAL JOURNAL OF OBESITY | 2006年 / 30卷 / 12期

关键词：

body mass index; gene-to-gene interaction; PPAR; polygenetic metabolism;

D O I：

10.1038/sj.ijo.0803345

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To investigate the association of a polymorphism at position 294 ( + 294T/C) in the Peroxisome Proliferator-activated Receptor delta (PPAR delta) with body mass index (BMI) and the additional role of a gene-to-gene interaction between PPAR delta, PPAR alpha and PPAR gamma. Design: An association between genetic variations in PPAR delta, PPAR alpha and PPAR gamma and indices of obesity and metabolism. Subjects: A group of 462 moderately obese (mean BMI 28.9 +/- 7.7) and dyslipidemic, middle-aged (mean age 43.9 +/- 13.7), Caucasion men and women. Measurements: The three most frequent single-nucleotide-polymorphisms (snp) in PPARd ( + 294T/C), PPAR alpha (L162V) and PPAR gamma (P12A) were genotyped and associated with clinical parameters. Results: The C allele in PPARd was significantly associated with a lower body mass index. Moreover an interaction between the polymorphisms in PPAR alpha and PPAR delta on body weight could be demonstrated. Conclusion: Our data provide further evidence for an involvement of PPARd in the regulation of BMI.

引用

页码：1709 / 1713

页数：5

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