A convenient method for the preparation of oxazaborolidine catalyst in situ using (S)-α,α-diphenylpyrrolidinemethanol, tetrabutylammonium borohydride, and methyl iodide for the asymmetric reduction of prochiral ketones

被引：15

作者：

Anwar, Shaik ^{[1
]}

Periasamy, Mariappan ^{[1
]}

机构：

[1] Univ Hyderabad, Sch Chem, Hyderabad 500046, Andhra Pradesh, India

来源：

TETRAHEDRON-ASYMMETRY | 2006年 / 17卷 / 23期

关键词：

D O I：

10.1016/j.tetasy.2006.11.032

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An oxazaborolidine catalyst is readily prepared in situ at 25 degrees C in THF using (S)-alpha,alpha-diphenylpyrrolidinemethanol and borane generated from tetrabutylammonium borohydride/CH3I reagent system. The oxazaborolidine/BH3 reagent system prepared in this way is useful for the reduction of prochiral ketones to the corresponding alcohols with up to 99% ee. (c) 2006 Elsevier Ltd. All rights reserved.

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页码：3244 / 3247

页数：4

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