The causative H+/K+ ATPase antigen in the pathogenesis of autoimmune gastritis

被引：79

作者：

Toh, BH ^{[1
]}

Sentry, JW ^{[1
]}

Alderuccio, F ^{[1
]}

机构：

[1] Monash Univ, Sch Med, Dept Pathol & Immunol, Melbourne, Vic 3181, Australia

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 07期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0167-5699(00)01653-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The gastric H+/K+ ATPase is the causative autoantigen recognised by CD4(+) T cells that mediate autoimmune gastritis. Pathogenic CD4(+) T cells are regulated by CD25(+)CD4(+) T cells. Here, it is proposed that waves of activation and migration of antigen presenting cells and CD4(+) T cells to and from the target organ and draining lymph node result in tissue damage.

引用

页码：348 / +

页数：10

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