Guest and subunit exchange in self-assembled ionophores

被引:22
作者
Cai, MM
Sidorov, V
Lam, YF
Flowers, RA
Davis, JT [1 ]
机构
[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA
[2] Univ Toledo, Dept Chem, Toledo, OH 43606 USA
关键词
D O I
10.1021/ol0058442
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[GRAPHICS] Self-assembled ionophores, formed by hydrogen bonding of isoG 1 around a cation, are dynamic structures. Multinuclear NMR spectroscopy in CD3CN-CDCl3 showed that cation exchange is >10(4) faster than exchange of isoG 1 ligand in (isoG 1)(10)-Cs+ Ph4B-. The cationic guest also affected the kinetic stability of the complex. 2D-EXSY NMR experiments in CDCl3 showed that ligand exchange was 2 orders of magnitude faster for the Li+-decamer than for the Cs+-decamer.
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页码:1665 / 1668
页数:4
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