MicroRNAs, development of Barrett's esophagus, and progression to esophageal adenocarcinoma

被引：78

作者：

Smith, Cameron M. ^{[1
]}

Watson, David I. ^{[1
]}

Michael, Michael Z. ^{[2
]}

Hussey, Damian J. ^{[1
]}

机构：

[1] Flinders Univ S Australia, Dept Surg, Flinders Med Ctr, Bedford Pk, SA 5042, Australia

[2] Flinders Univ S Australia, Dept Gastroenterol & Hepatol, Bedford Pk, SA 5042, Australia

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2010年 / 16卷 / 05期

关键词：

Barrett's esophagus; MicroRNA; Esophageal adenocarcinoma; Transdifferentiation; Tumour suppressor; HUMAN BREAST-CANCER; EXPRESSION PROFILES; SUPPRESSOR GENE; STEM-CELLS; MIRNAS; ACID; METASTASIS; METAPLASIA; CARCINOMA; MIR-21;

D O I：

10.3748/wjg.v16.i5.531

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Barrett's esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esophageal adenocarcinoma. Whilst it is well accepted that Barrett's esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated in most cellular processes, and the role of miRNAs in disease development is becoming increasingly evident. Understanding altered miRNA expression is likely to help unravel the molecular mechanisms that underpin the development of Barrett's esophagus and its progression to cancer. (C) 2010 Baishideng. All rights reserved.

引用

页码：531 / 537

页数：7

共 72 条

[1]

Role of microRNA-143 in Fas-mediated apoptosis in human T-cell leukemia Jurkat cells [J].

Akao, Yukihiro ;

Nakagawa, Yoshihito ;

Iio, Akio ;

Naoe, Tomoki .

LEUKEMIA RESEARCH, 2009, 33 (11) :1530-1538

[2]

[Anonymous], ANZ J SURG S1, DOI DOI 10.1111/J.1445-2197.2007.04122_X

[3]

Should patients with Barrett's oesophagus be kept under surveillance? The case for [J].

Armstrong, David .

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2008, 22 (04) :721-739

[4]

MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer [J].

Asangani, I. A. ;

Rasheed, S. A. K. ;

Nikolova, D. A. ;

Leupold, J. H. ;

Colburn, N. H. ;

Post, S. ;

Allgayer, H. .

ONCOGENE, 2008, 27 (15) :2128-2136

[5]

BOS JL, 1989, CANCER RES, V49, P4682

[6]

Role of retinoid X receptor mRNA expression in Barrett's esophagus [J].

Brabender, J ;

Lord, RV ;

Metzger, R ;

Park, J ;

Salonga, D ;

Danenberg, KD ;

Hölscher, AH ;

Danenberg, PV ;

Schneider, PM .

JOURNAL OF GASTROINTESTINAL SURGERY, 2004, 8 (04) :413-422

[7]

A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition [J].

Bracken, Cameron P. ;

Gregory, Philip A. ;

Kolesnikoff, Natasha ;

Bert, Andrew G. ;

Wang, Jun ;

Shannon, M. Frances ;

Goodall, Gregory J. .

CANCER RESEARCH, 2008, 68 (19) :7846-7854

[8]

p53-Responsive MicroRNAs 192 and 215 Are Capable of Inducing Cell Cycle Arrest [J].

Braun, Christian J. ;

Zhang, Xin ;

Savelyeva, Irina ;

Wolff, Sonja ;

Moll, Ute M. ;

Schepeler, Troels ;

Orntoft, Torben F. ;

Andersen, Claus L. ;

Dobbelstein, Matthias .

CANCER RESEARCH, 2008, 68 (24) :10094-10104

[9]

Sizing up miRNAs as cancer genes [J].

Caldas, C ;

Brenton, JD .

NATURE MEDICINE, 2005, 11 (07) :712-714

[10]

Retinoic acid-induced glandular differentiation of the oesophagus [J].

Chang, Chih-Long ;

Lao-Sirieix, Pierre ;

Save, Vicki ;

De La Cueva Mendez, Guillermo ;

Laskey, Ron ;

Fitzgerald, Rebecca C. .

GUT, 2007, 56 (07) :906-917

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